Arousal State-Dependence of Interactions Between Short- and Long-Term Auditory Novelty Responses in Human Subjects.
Arousal State-Dependence of Interactions Between Short- and Long-Term Auditory Novelty Responses in Human Subjects.
复制标题
DOI：
10.3389/fnhum.2021.737230
复制
发表时间：
2021
影响因子：
2.9
通讯作者：
Banks MI
中科院分区：
文献类型：
--
作者：
Nourski KV;Steinschneider M;Rhone AE;Mueller RN;Kawasaki H;Banks MI
在日常生活中，可预测的感官刺激通常不能提供生态信息。相比之下，新奇或意想不到的刺激标志着环境在生态上的显著变化。这一想法构成了预测编码假说的基础：有效的感觉编码将与可预测背景相关的神经活动降至最低，并强调对环境变化的检测。在现实生活中，大脑必须解决在不同时间尺度上发生的多个意想不到的感觉事件。局部/全局偏差实验范式考察了多个时间尺度上的听觉预测编码。对于短期的新颖性[数百毫秒；局部偏差(LD)]，相同声音的序列(/xxxxx/)会夹杂着包含偏差的序列(/xxxxy/)。使用(A)频繁/xxxxx/和不频繁/xxxxy/序列或(B)频繁/xxxxy/和不频繁/xxxxx/序列来创建长期新颖性[几秒；全局偏差(GD)]。在情景(A)中，既有LD效应，也有GD效应(LDGD，“双重惊喜”)。在(B)中，全局偏差是本地标准，即相同声音序列(LSGD)。反映LD和GD的皮质反应起源于不同的脑区，具有不同的时间进程，对全身麻醉具有不同的敏感性。LD和GD背后的神经过程已经被证明是相互作用的，反映了重叠的网络有助于检测新的听觉刺激。这项研究使用神经外科患者的颅内脑电图来检验这些相互作用。受试者在异丙酚麻醉诱导前和麻醉诱导期间进行GD靶点检测。录音来自清醒、镇静和无反应状态下的听觉皮质、周围听觉相关皮质和前额叶皮质。高伽马活性被用来测量局部和全局新奇事物相互作用的神经基础。正交互作用被定义为与LSGD相比，对双意外LDGD条件的更大反应。负交互作用被定义为对LDGD的较弱反应。正向交互作用比负向交互作用更常见，且主要见于听觉皮质。负性相互作用主要发生在前额叶皮质，对全身麻醉更为敏感。与颞顶听觉相关的区域表现出两种类型的交互作用。这些相互作用可能在临床环境中具有相关性，作为评估麻醉深度和意识障碍中意识知觉的生物标记物。
In everyday life, predictable sensory stimuli are generally not ecologically informative. By contrast, novel or unexpected stimuli signal ecologically salient changes in the environment. This idea forms the basis of the predictive coding hypothesis: efficient sensory encoding minimizes neural activity associated with predictable backgrounds and emphasizes detection of changes in the environment. In real life, the brain must resolve multiple unexpected sensory events occurring over different time scales. The local/global deviant experimental paradigm examines auditory predictive coding over multiple time scales. For short-term novelty [hundreds of milliseconds; local deviance (LD)], sequences of identical sounds (/xxxxx/) are interspersed with sequences that contain deviants (/xxxxy/). Long-term novelty [several seconds; global deviance (GD)] is created using either (a) frequent /xxxxx/ and infrequent /xxxxy/ sequences, or (b) frequent /xxxxy/ and infrequent /xxxxx/ sequences. In scenario (a), there is both an LD and a GD effect (LDGD, “double surprise”). In (b), the global deviant is a local standard, i.e., sequence of identical sounds (LSGD). Cortical responses reflecting LD and GD originate in different brain areas, have a different time course, and are differentially sensitive to general anesthesia. Neural processes underlying LD and GD have been shown to interact, reflecting overlapping networks subserving the detection of novel auditory stimuli. This study examined these interactions using intracranial electroencephalography in neurosurgical patients. Subjects performed a GD target detection task before and during induction of anesthesia with propofol. Recordings were made from the auditory cortex, surrounding auditory-related and prefrontal cortex in awake, sedated, and unresponsive states. High gamma activity was used to measure the neural basis of local-by-global novelty interactions. Positive interaction was defined as a greater response to the double surprise LDGD condition compared to LSGD. Negative interaction was defined as a weaker response to LDGD. Positive interaction was more frequent than negative interaction and was primarily found in auditory cortex. Negative interaction typically occurred in prefrontal cortex and was more sensitive to general anesthesia. Temporo-parietal auditory-related areas exhibited both types of interaction. These interactions may have relevance in a clinical setting as biomarkers of conscious perception in the assessment of depth of anesthesia and disorders of consciousness.
登录
查看更多内容
DOI：
10.1073/pnas.0809667106
发表时间：
2009-02-03
影响因子：
11.1
作者：
Bekinschtein, Tristan A.;Dehaene, Stanislas;Naccache, Lionel
通讯作者：
Naccache, Lionel
影响因子：
16.2
作者：
Bastos AM;Usrey WM;Adams RA;Mangun GR;Fries P;Friston KJ
通讯作者：
Friston KJ
DOI：
10.1523/jneurosci.3684-10.2011
发表时间：
2011-02-23
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Lerner Y;Honey CJ;Silbert LJ;Hasson U
通讯作者：
Hasson U
影响因子：
3
作者：
Grimm, Sabine;Escera, Caries
通讯作者：
Escera, Caries
影响因子：
1.9
作者：
MUMFORD, D
通讯作者：
MUMFORD, D