Prenatal risk factors for internalizing and externalizing problems in childhood.
Prenatal risk factors for internalizing and externalizing problems in childhood.
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DOI：
10.1007/s12519-019-00319-2
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发表时间：
2020-08
期刊：
影响因子：
--
通讯作者：
Liu J
中科院分区：
文献类型：
--
作者：
Tien J;Lewis GD;Liu J
越来越多的研究证明了产前风险因素对后代健康的影响。儿童期的行为问题，如外化和内化问题，也不例外。这一全面的文献综述旨在总结和综合目前的研究，常见的产前风险因素与内化和外化的问题，重点是他们在儿童和青少年时期的影响。潜在的机制以及影响也概述。EBSCO、Web of Science、PubMed、Google Scholar和Scopus数据库检索了研究产前风险因素与后代内化/外化问题之间的关联的研究，使用关键词“产前”或“围产期”或“分娩并发症”结合“内化”或“外化”。相关文献，包括实验研究，系统评价，荟萃分析，横向和纵向队列研究，和理论文献，进行了审查和综合，形成这个综合性审查的基础。关于后代内化和外化问题的产前风险因素已被广泛研究，包括与健康有关的风险因素，包括产妇超重/肥胖、物质使用/滥用、环境毒物暴露、产妇感染/炎症，以及心理社会风险因素，包括亲密伴侣暴力和焦虑/抑郁。总的来说，流行病学和实验研究都支持这些产前因素与儿童期及以后情绪/行为问题发展风险增加之间的不良关联。这些关联的潜在作用机制包括激素和免疫系统的改变。影响包括产前教育，筛查和干预策略。产前风险因素与后代的一系列内化和外化问题有关。识别这些风险因素并了解潜在的机制将有助于制定有效的循证预防和干预策略。
A growing body of research has documented the effects of prenatal risk factors on a wide spectrum of adverse offspring health outcomes. Childhood behavior problems, such as externalizing and internalizing problems, are no exception. This comprehensive literature review aims to summarize and synthesize current research about commonly experienced prenatal risk factors associated with internalizing and externalizing problems, with a focus on their impact during childhood and adolescence. Potential mechanisms as well as implications are also outlined. The EBSCO, Web of Science, PubMed, Google Scholar, and Scopus databases were searched for studies examining the association between prenatal risk factors and offspring internalizing/externalizing problems, using keywords “prenatal” or “perinatal” or “birth complications” in combination with “internalizing” or “externalizing”. Relevant articles, including experimental research, systematic reviews, meta-analyses, cross-sectional and longitudinal cohort studies, and theoretical literature, were reviewed and synthesized to form the basis of this integrative review. Prenatal risk factors that have been widely investigated with regards to offspring internalizing and externalizing problems encompass health-related risk factors, including maternal overweight/obesity, substance use/abuse, environmental toxicant exposure, maternal infection/inflammation, as well as psychosocial risk factors, including intimate partner violence, and anxiety/depression. Collectively, both epidemiological and experimental studies support the adverse associations between these prenatal factors and increased risk of emotional/behavioral problem development during childhood and beyond. Potential mechanisms of action underlying these associations include hormonal and immune system alterations. Implications include prenatal education, screening, and intervention strategies. Prenatal risk factors are associated with a constellation of offspring internalizing and externalizing problems. Identifying these risk factors and understanding potential mechanisms will help to develop effective, evidence-based prevention, and intervention strategies.
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DOI：
10.1002/oby.22070
发表时间：
2018-03
期刊：
Obesity (Silver Spring, Md.)
影响因子：
--
作者：
Cahill AG;Haire-Joshu D;Cade WT;Stein RI;Woolfolk CL;Moley K;Mathur A;Schechtman K;Klein S
通讯作者：
Klein S
影响因子：
5
作者：
Burns, JM;Baghurst, PA;Tong, SL
通讯作者：
Tong, SL
DOI：
10.1097/chi.0b013e318172eefb
发表时间：
2008-07-01
影响因子：
13.3
作者：
Ashford, Janka;van Lier, Pol A. C.;Koot, Hans M.
通讯作者：
Koot, Hans M.
影响因子：
3.5
作者：
Blackmore, Emma Robertson;Mittal, Mona;O'Connor, Thomas G.
通讯作者：
O'Connor, Thomas G.
影响因子：
15.1
作者：
Babri, Shirin;Doosti, Mohammad-Hossein;Salari, Ali-Akbar
通讯作者：
Salari, Ali-Akbar