Deficits in attentional control: cholinergic mechanisms and circuitry-based treatment approaches.
Deficits in attentional control: cholinergic mechanisms and circuitry-based treatment approaches.
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DOI：
10.1037/a0026227
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发表时间：
2011-12
影响因子：
1.9
通讯作者：
Paolone, Giovanna
中科院分区：
文献类型：
--
作者：
Sarter, Martin;Paolone, Giovanna
注意力的认知控制包括在工作记忆（或“在线”）中维持任务规则，监控奖励和错误率，过滤干扰因素，以及抑制优势和竞争反应。弱的注意力控制会增加注意力分散，导致注意力缺失、冲动和注意力疲劳。紧张性胆碱能活动的水平（在几十秒或几分钟内发生变化）根据对认知控制的需求来调节皮质回路。增加胆碱能调制增强的代表性的线索，通过增强线索诱发的活动在丘脑神经元传入，从而提高检测率。这种胆碱能调节主要通过α4β2* 烟碱乙酰胆碱受体介导。在ADHD成人患者中进行的动物实验和临床试验表明，刺激这种受体的药物可能会使注意力症状和障碍受益。紧张性胆碱能调制的线索诱发的前额叶区的脑电瞬变是大脑的执行电路的重要组成部分。这种电路模型指导注意力控制缺陷治疗的发展。
The cognitive control of attention involves maintaining task rules in working memory (or “online”), monitoring reward and error rates, filtering distractors, and suppressing prepotent and competitive responses. Weak attentional control increases distractibility and causes attentional lapses, impulsivity and attentional fatigue. Levels of tonic cholinergic activity (changes over tens of seconds or minutes) modulate cortical circuitry as a function of the demands on cognitive control. Increased cholinergic modulation enhances the representation of cues, by augmenting cue-evoked activity in thalamic glutamatergic afferents, thereby increasing the rate of detection. Such cholinergic modulation is mediated primarily via α4β2* nicotinic acetylcholine receptors. Animal experiments and clinical trials in adult patients with ADHD indicate that attentional symptoms and disorders may benefit from drugs that stimulate this receptor. Tonic cholinergic modulation of cue-evoked glutamatergic transients in prefrontal regions is an essential component of the brain’s executive circuitry. This circuitry model guides the development of treatments of deficits in attentional control.
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影响因子：
3.3
作者：
Arnold, HM;Burk, JA;Bruno, JP
通讯作者：
Bruno, JP
影响因子：
3.6
作者：
DOUGLAS, VI;PARRY, PA
通讯作者：
PARRY, PA
影响因子：
3.6
作者：
Carte, ET;Nigg, JT;Hinshaw, SP
通讯作者：
Hinshaw, SP
影响因子：
17.7
作者：
Elvevåg, B;Weinberger, DR;Goldberg, TE
通讯作者：
Goldberg, TE
DOI：
10.1523/jneurosci.4515-08.2009
发表时间：
2009-04-08
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Croxson PL;Walton ME;O'Reilly JX;Behrens TE;Rushworth MF
通讯作者：
Rushworth MF