Green Nanotechnology from Cumin Phytochemicals: Generation of Biocompatible Gold Nanoparticles.

Green Nanotechnology from Cumin Phytochemicals: Generation of Biocompatible Gold Nanoparticles.
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小茴香植物化学品的绿色纳米技术:生物相容性金纳米颗粒的生成。

DOI:
10.1080/19430850902931599
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发表时间:
2009
期刊:
International journal of green nanotechnology. Biomedicine
影响因子:
--
通讯作者:
Katti,KatteshV
Katti,KatteshV
中科院分区:
--
文献类型:
--
作者:
Katti,Kavita;Chanda,Nripen;Shukla,Ravi;Zambre,Ajit;Suibramanian,Thilakavathi;Kulkarni,RajeshR;Kannan,Raghuraman;Katti,KatteshV

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小茴香中各种植物化学物质的强大抗氧化特性促使我们测试它们在将四氯酸钠还原成相应的金纳米颗粒方面的功效。在此,我们报告了一种前所未有的合成路线,通过简单地将孜然与四氯金酸钠水溶液混合,生产出定义良好的球形金纳米颗粒。在这种孜然介导的绿色纳米工艺中,金纳米颗粒的生产是在生物良性条件下实现的。通过孜然介导的过程产生的金纳米颗粒没有聚集,这表明包括蛋白质在内的植物化学物质的混合物可以作为纳米颗粒的优良涂层,从而提供强大的屏蔽聚集。此外,在正常成纤维细胞上进行的详细MTT试验表明,纳米颗粒上的植物化学涂层呈现出这些“绿金纳米颗粒”的无毒特征。本文讨论了我们的研究结果,提出了一种新的“纳米-自然”连接,用于生产和利用金纳米颗粒在纳米医学和纳米技术中的潜在应用。
The powerful antioxidant characteristics of various phytochernicals within cumin prompted us to test their efficacy in reducing sodium tetrachloroaurate to corresponding gold nanoparticles. We, herein, report an unprecedented synthetic route that involves the production of well-defined spherical gold nanoparticles by simple mixing of cumin to an aqueous solution of sodium tetrachloro aurate. Production of gold nanoparticles in this cumin–mediatedGreen Nanotechnologicalprocess is achieved under biologically benign conditions. The gold nanoparticles generated through cumin-mediated process did not aggregate suggesting that the cocktail of phytochemicals including proteins serve as excellent coatings on nanoparticles and thus, provide robust shielding from aggregations. In addition, the phytochemical coatings on nanoparticles have rendered nontoxic features to these ‘Green Gold Nanoparticles’ as demonstrated through detailed MTT assays performed on 'normal fibroblast cells. Results of our studies presenting a new ‘Nano-Naturo’ connection for the production and utility of gold nanoparticles for potential applications in nanomedicine and nanotechnology are discussed in this paper.
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