Microchimerism in endocrine pathology.
Microchimerism in endocrine pathology.
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DOI：
10.1007/s12022-009-9064-4
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发表时间：
2009
影响因子：
4.4
通讯作者：
Bianchi DW
中科院分区：
文献类型：
--
作者：
Rust DW;Bianchi DW
嵌合现象是指两种不同生物体的细胞共存。它可以通过移植或输血引起医源性，也可以通过双胞胎之间的转移或怀孕期间母亲和胎儿之间的贩运引起生理性。许多与微嵌合体相关的疾病影响内分泌系统（例如，自身免疫性甲状腺疾病和1型糖尿病）。微嵌合体与内分泌病理学有关，因为（a）它与妊娠有关，这是一种复杂的内分泌生理学状况;（B）母胎和胎-母细胞迁移必须涉及胎盘，胎盘本身是一种内分泌器官;（c）在某些物种中，嵌合体导致中间性状态，这是一种与内分泌生理学密切相关的状况。对甲状腺中胎儿-母体微嵌合体的研究已经证实了胎儿细胞的存在与桥本甲状腺炎、Graves病、甲状腺腺瘤和甲状腺乳头状癌有关。母胎微嵌合体的研究已经证明了母体细胞在青少年糖尿病和其他儿科疾病中的存在。微嵌合体在病变甲状腺和胰腺组织的修复中起着潜在的作用。
Chimerism in an individual refers to the coexistence of cells arising from two distinct organisms. It can arise iatrogenically via transplant or blood transfusion, and physiologically via twin to twin transfer, or from trafficking between mother and fetus during pregnancy. Many of the diseases associated with microchimerism affect the endocrine system (e.g., autoimmune thyroid disease and diabetes mellitus type 1). Microchimerism is relevant to endocrine pathology because (a) it is associated with pregnancy, a condition of complex endocrine physiology; (b) maternofetal and feto-maternal cellular migration must involve the placenta, itself an endocrine organ; and (c) in some species, chimerism results in states of intersexuality, a condition intimately involved with endocrine physiology. Studies of feto-maternal microchimerism in the thyroid have documented the presence of fetal cells in association with Hashimoto thyroiditis, Graves’ disease, thyroid adenoma, and papillary thyroid carcinoma. Studies of materno-fetal microchimerism have documented the presence of maternal cells in juvenile diabetes and other pediatric conditions. Microchimerism plays a potential role in the repair of diseased thyroid and pancreatic tissues.
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影响因子：
5.8
作者：
Renné, C;Lopez, ER;Badenhoop, K
通讯作者：
Badenhoop, K
影响因子：
1.9
作者：
Stevens, Anne M.;Hermes, Heidi M.;Nelson, J. Lee
通讯作者：
Nelson, J. Lee
影响因子：
5.8
作者：
Walsh, JP;Bremner, AP;Michelangeli, V
通讯作者：
Michelangeli, V
影响因子：
168.9
作者：
Nelson, JL;Furst, DE;Bianchi, DW
通讯作者：
Bianchi, DW
DOI：
10.1016/j.beem.2004.03.002
发表时间：
2004-06-01
影响因子：
7.4
作者：
Ando, T;Davies, TF
通讯作者：
Davies, TF