Metabolic risk in older adults is associated with impaired sustained attention.
Metabolic risk in older adults is associated with impaired sustained attention.
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老年人的代谢风险与持续注意力受损有关。
DOI：
10.1037/neu0000554
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发表时间：
2019
期刊：
影响因子：
2.4
通讯作者：
Leritz,Elizabeth
中科院分区：
文献类型：
--
作者：
Wooten,Thomas;Ferland,Tori;Poole,Victoria;Milberg,William;McGlinchey,Regina;DeGutis,Joseph;Esterman,Michael;Leritz,Elizabeth
目的代谢综合征是指存在三个或三个以上心血管危险因素的疾病，它与细微的弥漫性神经损害有关，但与认知功能障碍的关系并不一致。持续注意力是一种基本的认知操作，它依赖于多个大脑网络，并在广泛的神经疾病中受损。方法我们评估了93名中老年人(45-75岁)的血管危险因素(VRF；血压、腰围、胆固醇、葡萄糖和甘油三酯)。METS是根据国家胆固醇教育计划成人培训计划(NCEP ATPIII)的当前指南定义的。参与者根据VRF的数量进行分组：高风险(METS；3+VRF；N=32)、中等风险(1或2 VRF；N=35)和低风险(0 VRF；N=26)。所有参与者都接受了一系列神经心理学测试，以衡量执行功能。结果VRF组对持续性注意表现有显著的主效应，血管风险较低的受试者能够更好地维持注意力。在执行功能的标准神经心理学测试中未检测到显著影响。结论我们的结果表明，分级CPT对蛋氨酸对神经认知功能的细微方面的潜在负面影响很敏感。
ObjectiveMetabolic syndrome (MetS), the presence of three or more cardiovascular risk factors, has been associated with subtle and diffuse neural compromise but has not been consistently associated with cognitive dysfunction. Sustained attention is a fundamental cognitive operation that relies on multiple brain networks and is impaired in a broad array of neurologic conditions. We examined whether a well-validated measure of sustained attention would be sensitive to vascular risk, as compared with more standard neuropsychological measures of attention and executive functioning.MethodWe assessed vascular risk factors (VRFs; blood pressure, waist circumference, cholesterol, glucose, and triglycerides) in 93 middle-to-older aged adults (45–75 years). MetS was defined based on current guidelines from the National Cholesterol Education Program Adult Training Program (NCEP ATP III). Participants were grouped according to number of VRFs: high risk (MetS; 3+ VRFs; N= 32), medium risk (1 or 2 VRFs; N= 35), and low risk (0 VRFs; N= 26). All participants underwent a neuropsychological battery of tests measuring executive functioning. Participants also performed the gradual-onset continuous performance task (gradCPT), a measure of sustained attention.ResultsThere was a significant main effect of VRF group on sustained attention performance; participants with lower vascular risk were better able to sustain attention. No significant effects were detected on standard neuropsychological tests of executive function.ConclusionOur results suggest that the gradCPT is sensitive to the potentially negative effects of MetS on subtle aspects of neurocognitive functioning.
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