A broken filter: prefrontal functional connectivity abnormalities in schizophrenia during working memory interference.
A broken filter: prefrontal functional connectivity abnormalities in schizophrenia during working memory interference.
复制标题
DOI：
10.1016/j.schres.2012.07.007
复制
发表时间：
2012-10
影响因子：
4.5
通讯作者：
Barch DM
中科院分区：
文献类型：
--
作者：
Anticevic A;Repovs G;Krystal JH;Barch DM
鉴于认知缺陷对患者生活结局的影响，描述工作记忆（WM）异常是精神分裂症研究的一个基本挑战。在之前的工作中，我们证明了健康对照者背外侧前额叶皮层 (DLPFC) 的激活与 WM 期间成功的干扰干扰抵抗有关，但在精神分裂症患者中则不然。尽管了解区域功能缺陷的影响至关重要，但 WM 网络内节点之间的功能连接异常可能构成 WM 损伤的最终共同途径。因此，本研究检验了这样的假设：精神分裂症与 WM 分心情况下 DLPFC 网络内的功能连接异常有关。 28 名患者和 24 名对照者完成了延迟的非语言 WM 任务，其中包括 WM 维持阶段的短暂视觉干扰。我们特别在存在或不存在分心的维持阶段计算了 DLPFC 全脑基于任务的功能连接 (tb-fcMRI)。结果显示，在皮质和皮质下区域的干扰物呈现期间，患者未能调节 tb-fcMRI。具体来说，对照表明，当存在注意力分散时，DLPFC 和扩展杏仁核之间的 tb-fcMRI 会减少。相反，患者未能表现出与杏仁核耦合的变化，但表现出与内侧丘脑的连接性更强。虽然对照组在干扰物呈现过程中显示 DLPFC 和其他前额皮质区域之间存在更积极的耦合，但患者未能表现出这种调节。总而言之，这些发现支持这样的观点，即观察到的干扰阻力缺陷涉及 DLPFC 和分布式区域之间的耦合破坏，包括皮质下（丘脑/边缘）和控制区域连接。
Characterizing working memory (WM) abnormalities represents a fundamental challenge in schizophrenia research given the impact of cognitive deficits on life outcome in patients. In prior work we demonstrated that dorsolateral prefrontal cortex (DLPFC) activation was related to successful distracter resistance during WM in healthy controls, but not in schizophrenia. Although understanding the impact of regional functional deficits is critical, functional connectivity abnormalities among nodes within WM networks may constitute a final common pathway for WM impairment. Therefore, this study tested the hypothesis that schizophrenia is associated with functional connectivity abnormalities within DLPFC networks during distraction conditions in WM. 28 patients and 24 controls completed a delayed non-verbal WM task that included transient visual distraction during the WM maintenance phase. We computed DLPFC whole-brain task-based functional connectivity (tb-fcMRI) specifically during the maintenance phase in the presence or absence of distraction. Results revealed that patients failed to modulate tb-fcMRI during distracter presentation in both cortical and sub-cortical regions. Specifically, controls demonstrated reductions in tb-fcMRI between DLPFC and the extended amygdala when distraction was present. Conversely, patients failed to demonstrate a change in coupling with the amygdala, but showed greater connectivity with medio-dorsal thalamus. While controls showed more positive coupling between DLPFC and other prefrontal cortical regions during distracter presentation, patients failed to exhibit such a modulation. Taken together, these findings support the notion that observed distracter resistance deficit involves a breakdown in coupling between DLPFC and distributed regions, encompassing both subcortical (thalamic/limbic) and control region connectivity.
登录
查看更多内容
DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
在认知控制性能过程中，第一期精神分裂症中的一般和特定的功能连通性干扰。
影响因子：
10.6
作者：
Fornito, Alex;Yoon, Jong;Zalesky, Andrew;Bullmore, Edward T.;Carter, Cameron S.
通讯作者：
Carter, Cameron S.
影响因子：
5.3
作者：
Green, Michael F.
通讯作者：
Green, Michael F.
影响因子：
3.3
作者：
Cornblatt, B;Obuchowski, M;Erlenmeyer-Kimling, L
通讯作者：
Erlenmeyer-Kimling, L
影响因子：
6.6
作者：
Delawalla, Zainab;Barch, Deanna M.;Csernansky, John G.
通讯作者：
Csernansky, John G.