Asynchronous magnetic resonance elastography: Shear wave speed reconstruction using noise correlation of incoherent waves.
Asynchronous magnetic resonance elastography: Shear wave speed reconstruction using noise correlation of incoherent waves.
复制标题
异步磁共振弹性图：使用不连贯波的噪声相关的剪切波速度重建。
DOI：
10.1002/mrm.29502
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发表时间：
2023-03
影响因子：
3.3
通讯作者：
Nguyen, Christopher T.
中科院分区：
文献类型：
--
作者：
Nguyen, Khoi D.;Bonner, Benjamin P.;Foster, Anna N.;Sadighi, Mehdi;Nguyen, Christopher T.
生物组织弹性的非侵入性测量是一种不断发展的技术，能够为广泛的生物医学工程和临床应用提供软组织力学的强大表征。我们提出，设计，并在这里实现一种新的MRI技术称为异步磁共振弹性成像（aMRE），推动测量技术实现无人驾驶。该技术可以添加到临床MRI扫描仪中，而无需任何额外的专用硬件。异步MRE建立在扩散波场和噪声相关性的理论基础上，以前在超声中开发，以利用看似不相干的波场重建剪切波速度。与解决逆问题的传统弹性成像方法不同，aMRE使用测量波场的时空统计数据直接重建波速的逐像素映射。不连贯的手指敲击作为所有aMRE测量的波源。使用Siemens Prismafit在体模上进行异步MRE，作为理论的实验验证。作为使用Siemens Skyra扫描仪的体内成像的概念验证实施，进一步在大腿肌肉上进行。数值和幻影实验表明，从看似嘈杂的波场的波速的准确重建。概念验证大腿实验还表明，aMRE协议可以重建波速的逐像素映射。异步MRE被证明可以在体模实验中准确重建剪切波速度，并且仍处于体内成像的概念验证阶段。经过进一步的验证和改进，它有可能降低测量组织弹性的技术和资金壁垒。
The noninvasive measurement of biological tissue elasticity is an evolving technology that enables the robust characterization of soft tissue mechanics for a wide array of biomedical engineering and clinical applications. We propose, design, and implement here a new MRI technique termed asynchronous magnetic resonance elastography (aMRE) that pushes the measurement technology toward a driverless implementation. This technique can be added to clinical MRI scanners without any additional specialized hardware. Asynchronous MRE is founded on the theory of diffuse wavefields and noise correlation previously developed in ultrasound to reconstruct shear wave speeds using seemingly incoherent wavefields. Unlike conventional elastography methods that solve an inverse problem, aMRE directly reconstructs a pixel‐wise mapping of wave speed using the spatial–temporal statistics of the measured wavefield. Incoherent finger tapping served as the wave‐generating source for all aMRE measurements. Asynchronous MRE was performed on a phantom using a Siemens Prismafit as an experimental validation of the theory. It was further performed on thigh muscles as a proof‐of‐concept implementation of in vivo imaging using a Siemens Skyra scanner. Numerical and phantom experiments show an accurate reconstruction of wave speeds from seemingly noisy wavefields. The proof‐of‐concept thigh experiments also show that the aMRE protocol can reconstruct a pixel‐wise mapping of wave speeds. Asynchronous MRE is shown to accurately reconstruct shear wave speeds in phantom experiments and remains at the proof‐of‐concept stage for in vivo imaging. After further validation and improvements, it has the potential to lower both the technical and monetary barriers of entry to measuring tissue elasticity.
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影响因子：
3.7
作者：
Andonian P;Viallon M;Le Goff C;de Bourguignon C;Tourel C;Morel J;Giardini G;Gergelé L;Millet GP;Croisille P
通讯作者：
Croisille P
影响因子：
3.3
作者：
Layton, Kelvin J.;Kroboth, Stefan;Zaitsev, Maxim
通讯作者：
Zaitsev, Maxim
影响因子：
3.3
作者：
Stalder, A. F.;Russe, M. F.;Markl, M.
通讯作者：
Markl, M.
影响因子：
3.3
作者：
Nguyen, Christopher;Fan, Zhaoyang;Li, Debiao
通讯作者：
Li, Debiao
影响因子：
56.9
作者：
MUTHUPILLAI, R;LOMAS, DJ;EHMAN, RL
通讯作者：
EHMAN, RL