Fatality risks for nosocomial outbreaks of Middle East respiratory syndrome coronavirus in the Middle East and South Korea.
Fatality risks for nosocomial outbreaks of Middle East respiratory syndrome coronavirus in the Middle East and South Korea.
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DOI：
10.1007/s00705-016-3062-x
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发表时间：
2017-01
影响因子：
2.7
通讯作者：
Liu S
中科院分区：
文献类型：
--
作者：
Sha J;Li Y;Chen X;Hu Y;Ren Y;Geng X;Zhang Z;Liu S
中东呼吸综合征冠状病毒（MERS-CoV）于2012年首次分离出来。中东以外最大的已知疫情发生在2015年的韩国。截至2016年6月29日，26个国家报告了1769例实验室确诊病例（630例死亡;病死率[CFR]为35.6%），特别是在中东。然而，在中东和韩国，医院暴发的CFR高于家庭聚集性暴发的CFR。在这里，我们比较了中东51起医院暴发和韩国MERS-CoV暴发的死亡率。我们的研究结果显示，中东的CFR远高于韩国（25.9%[56/216] vs. 13.8%[24/174]，p = 0.003）。死亡的感染者平均年龄大于中东（64岁[25-98] vs. 46岁[2-85]，p = 0.000）和韩国（68岁[49-82] vs. 53.5岁[16-87]，p = 0.000）的幸存者。同样，在中东（64.3%[36/56] vs. 28.1%[45/160]，p = 0.000）和韩国（45.8%[11/24] vs. 12.0%[18/150]，p = 0.000），致死性病例的共病率在统计学上高于非致死性病例。死亡病例从发病到确认感染的中位天数长于中东幸存者（8天[1-47] vs. 4天[0-14]，p = 0.009）。因此，在中东和韩国，年龄较大、先前存在的并发疾病和延迟确认增加了MERS-CoV医院内暴发的致命结局的几率。本文的在线版本（doi：10.1007/s 00705 -016-3062-x）包含补充材料，可供授权用户使用。
Middle East respiratory syndrome coronavirus (MERS-CoV) was first isolated in 2012. The largest known outbreak outside the Middle East occurred in South Korea in 2015. As of 29 June 2016, 1769 laboratory-confirmed cases (630 deaths; 35.6 % case fatality rate [CFR]) had been reported from 26 countries, particularly in the Middle East. However, the CFR for hospital outbreaks was higher than that of family clusters in the Middle East and Korea. Here, we compared the mortality rates for 51 nosocomial outbreaks in the Middle East and one outbreak of MERS-CoV in South Korea. Our findings showed the CFR in the Middle East was much higher than that in South Korea (25.9 % [56/216] vs. 13.8 % [24/174], p = 0.003). Infected individuals who died were, on average, older than those who survived in both the Middle East (64 years [25–98] vs. 46 years [2–85], p = 0.000) and South Korea (68 years [49–82] vs. 53.5 years [16–87], p = 0.000). Similarly, the co-morbidity rates for the fatal cases were statistically higher than for the nonfatal cases in both the Middle East (64.3 % [36/56] vs. 28.1 % [45/160], p = 0.000) and South Korea (45.8 % [11/24] vs. 12.0 % [18/150], p = 0.000). The median number of days from onset to confirmation of infection in the fatal cases was longer than that for survivors from the Middle East (8 days [1–47] vs. 4 days [0–14], p = 0.009). Thus, older age, pre-existing concurrent diseases, and delayed confirmation increase the odds of a fatal outcome in nosocomial MERS-CoV outbreaks in the Middle East and South Korea. The online version of this article (doi:10.1007/s00705-016-3062-x) contains supplementary material, which is available to authorized users.
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影响因子：
1.6
作者：
Khalid M;Khan B;Al Rabiah F;Alismaili R;Saleemi S;Rehan-Khaliq AM;Weheba I;Al Abdely H;Halim M;Nadri QJ;Al Dalaan AM;Zeitouni M;Butt T;Al Mutairy E
通讯作者：
Al Mutairy E
DOI：
10.1093/cid/ciu812
发表时间：
2015-02-01
期刊：
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
影响因子：
--
作者：
Drosten C;Muth D;Corman VM;Hussain R;Al Masri M;HajOmar W;Landt O;Assiri A;Eckerle I;Al Shangiti A;Al-Tawfiq JA;Albarrak A;Zumla A;Rambaut A;Memish ZA
通讯作者：
Memish ZA
中东呼吸道综合征和严重急性呼吸道综合征冠状病毒在医疗保健人员中的人类感染的比较流行病学。
影响因子：
3.7
作者：
Liu S;Chan TC;Chu YT;Wu JT;Geng X;Zhao N;Cheng W;Chen E;King CC
通讯作者：
King CC
影响因子：
11.8
作者：
Assiri A;Abedi GR;Bin Saeed AA;Abdalla MA;al-Masry M;Choudhry AJ;Lu X;Erdman DD;Tatti K;Binder AM;Rudd J;Tokars J;Miao C;Alarbash H;Nooh R;Pallansch M;Gerber SI;Watson JT
通讯作者：
Watson JT
影响因子：
3.8
作者：
Chowell G;Blumberg S;Simonsen L;Miller MA;Viboud C
通讯作者：
Viboud C