Middle Eastern Respiratory Syndrome Corona Virus (MERS CoV): case reports from a tertiary care hospital in Saudi Arabia.
Middle Eastern Respiratory Syndrome Corona Virus (MERS CoV): case reports from a tertiary care hospital in Saudi Arabia.
复制标题
DOI：
10.5144/0256-4947.2014.396
复制
发表时间：
2014-09
影响因子：
1.6
通讯作者：
Al Mutairy E
中科院分区：
文献类型：
--
作者：
Khalid M;Khan B;Al Rabiah F;Alismaili R;Saleemi S;Rehan-Khaliq AM;Weheba I;Al Abdely H;Halim M;Nadri QJ;Al Dalaan AM;Zeitouni M;Butt T;Al Mutairy E
由新型冠状病毒（MERS CoV）引起的中东呼吸综合征自2012年在沙特阿拉伯首次被描述以来一直是一个重大的公共卫生挑战。迄今为止，这种严重的疾病没有有效的治疗方法，其特点是死亡率高。我们报告了在三级医院使用利巴韦林和干扰素（IFN）-α2b治疗MERS CoV的初步经验。6例确诊为MERS CoV的患者在支持性治疗的基础上接受了利巴韦林和IFN-α2b治疗。记录患者的人口统计学资料、临床参数和结局。对这些患者的54名密切接触者进行了MERS CoV筛查。本研究纳入了6例MERS CoV感染患者。4例病例有症状，包括肺炎和呼吸衰竭，2例为MERS CoV患者的无症状密切接触者。MERS CoV感染通过逆转录-聚合酶链反应检测痰液样本上E基因（UPE）上游的共有病毒RNA靶标和开放阅读框（ORF 1b）来确认。记录患者的人口统计学资料、共病情况、诊断和开始治疗的时间以及临床结果。6名患有合并症的患者中有3名在研究期间死亡，3名患者取得了成功的结果。死亡患者的诊断和治疗平均延迟15天。在54名接受筛查的密切接触者中，只有2人（3.7%）对MERS CoV呈阳性。利巴韦林和IFN-α2b治疗MERS CoV感染患者可能有效。在MERS CoV患者的密切接触者中，感染率似乎较低。
Middle Eastern respiratory syndrome caused by novel coronavirus (MERS CoV) has been a major public health challenge since it was first described in 2012 in Saudi Arabia. So far, there is no effective treatment for this serious illness, which features a high mortality rate. We report an initial experience of the use of ribavirin and interferon (IFN)-α2b in the management of MERS CoV at a tertiary care hospital. A case series of 6 patients admitted with a confirmed diagnosis of MERS CoV were treated with ribavirin and IFN-α2b in addition to supportive management. The patients’ demographics, clinical parameters, and outcomes were recorded. Fifty-four close contacts of these patients were screened for MERS CoV. Six patients with MERS CoV infection were included in this study. Four cases featured symptomatic disease, including pneumonia and respiratory failure, while 2 were asymptomatic close contacts of the MERS CoV patients. The MERS CoV infection was confirmed by reverse transcription–polymerase chain reaction detection of the consensus viral RNA targets upstream of the E gene (UPE) and open reading frame (ORF1b) on a sputum sample. The patients’ demographics, comorbid conditions, time to diagnosis and initiation of treatment, and clinical outcomes were recorded. Three out of 6 patients who had comorbid conditions died during the study period, while 3 had successful outcomes. The diagnosis and treatment was delayed by an average of 15 days in those patients who died. Only 2 close contacts out of the 54 screened (3.7%) were positive for MERS CoV. Treatment with ribavirin and IFN-α2b may be effective in patients infected with MERS CoV. There appears to be a low infectivity rate among close contacts of MERS CoV patients.
登录
查看更多内容
影响因子：
6.4
作者：
Alagaili AN;Briese T;Mishra N;Kapoor V;Sameroff SC;Burbelo PD;de Wit E;Munster VJ;Hensley LE;Zalmout IS;Kapoor A;Epstein JH;Karesh WB;Daszak P;Mohammed OB;Lipkin WI
通讯作者：
Lipkin WI
DOI：
10.1016/j.ijid.2013.07.002
发表时间：
2013-10
期刊：
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
影响因子：
--
作者：
Momattin H;Mohammed K;Zumla A;Memish ZA;Al-Tawfiq JA
通讯作者：
Al-Tawfiq JA
影响因子：
82.9
作者：
通讯作者：
--
DOI：
10.1016/j.ijid.2013.12.003
发表时间：
2014-03
期刊：
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
影响因子：
--
作者：
Al-Tawfiq JA;Momattin H;Dib J;Memish ZA
通讯作者：
Memish ZA
影响因子：
158.5
作者：
Zaki, Ali Moh;van Boheemen, Sander;Fouchier, Ron A. M.
通讯作者：
Fouchier, Ron A. M.