Contributions of the Kölliker-Fuse nucleus to coordination of breathing and swallowing.

Contributions of the Kölliker-Fuse nucleus to coordination of breathing and swallowing.
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DOI:
10.1016/j.resp.2013.06.003
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发表时间:
2013-10-01
影响因子:
2.3
通讯作者:
Forster, H. V.
Forster, H. V.
中科院分区:
医学4区
文献类型:
--
作者:
Bonis, J. M.;Neumueller, S. E.;Krause, K. L.;Pan, L. G.;Hodges, M. R.;Forster, H. V.

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在此,我们比较了Kölliker-Fuse核(KFN)和外侧(LPBN)和内侧(MPBN)臂旁核的扰动对呼吸和吞咽协调的影响。山羊在清醒状态下长期插管,注射伊博tenic酸(IA)。呼气晚期(E)的燕子总是重置呼吸节奏,而吸气早期(I)的燕子从不重置呼吸节奏。插管前其他E、I咽药均未复位呼吸节律,对E、I持续时间及潮气量(VT)影响较小。然而,在MPBN和KFN中植入插管后,E和I型燕子重置呼吸节律,增加了对I和E持续时间和VT的影响。随后在KFN中注射IA消除了燕子的呼吸期重置,但加剧了对I和E持续时间和VT的影响。我们得出结论,KFN和MPBN在较小程度上有助于呼吸和吞咽的协调。
Herein we compare the effects of perturbations in the Kölliker–Fuse nucleus (KFN) and the lateral (LPBN) and medial (MPBN) parabrachial nuclei on the coordination of breathing and swallowing. Cannula was chronically implanted in goats through which ibotenic acid (IA) was injected while awake. Swallows in late expiration (E) always reset while swallows in early inspiration (I) never reset the respiratory rhythm. Before cannula implantation, all other E and I swallows did not reset the respiratory rhythm, and had small effects on E and I duration and tidal volume (VT). However, after cannula implantation in the MPBN and KFN, E and I swallows reset the respiratory rhythm and increased the effects on I and E duration and VT. Subsequent injection of IA into the KFN eliminated the respiratory phase resetting of swallows but exacerbated the effects on I and E duration and VT. We conclude that the KFN and to a lesser extent the MPBN contribute to coordination of breathing and swallowing.
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