Inverted-U shaped effects of D1 dopamine receptor stimulation in the medial preoptic nucleus on sexually motivated song in male European starlings.
Inverted-U shaped effects of D1 dopamine receptor stimulation in the medial preoptic nucleus on sexually motivated song in male European starlings.
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DOI：
10.1111/ejn.12429
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发表时间：
2014-02
期刊：
影响因子：
--
通讯作者：
Stevenson SA
中科院分区：
文献类型：
--
作者：
Riters LV;Pawlisch BA;Kelm-Nelson CA;Stevenson SA
过去的研究在鸣禽突出了中央的作用，内侧视前核（mPOA）在上下文适当的声音通信。在繁殖季节，雄性鸣禽唱歌主要是为了吸引雌性（性动机歌曲）和击退竞争对手（竞争动机歌曲）。过去的数据将mPOA中的多巴胺和D1多巴胺受体与性动机的歌曲联系起来，但与激动性动机的歌曲无关;然而，mPOA中多巴胺受体操纵对歌曲的直接影响尚未经过实验测试。在这里，我们测试的假设，D1受体刺激的mPOA选择性地影响性动机的男性歌曲和D1激动的效果不同，在低和高剂量的可能性。在第一项研究中，繁殖条件下的雄性欧洲椋鸟在不同的测试日接受生理盐水或单剂量的D1受体激动剂SKF 38393输注到mPOA或下丘脑对照区。刺激mPOA中的D1受体触发性动机，但不是激动性动机的歌曲。第二项研究显示了激动剂的倒U形剂量反应效应，使得在低水平和高水平的D1受体激活下观察到低水平的性动机歌曲。第三项研究表明，D1受体拮抗剂SCH 23390可阻断D1激动剂的作用。这些研究结果表明，需要一个最佳水平的D1多巴胺受体刺激mPOA，以促进性动机的发声。研究结果支持中央，特定于上下文的mPOA在声乐交流中的作用，更广泛地展示了一个复杂的，调制的影响，在mPOA的D1受体的性动机行为。
Past studies in songbirds highlight a central role for the medial preoptic nucleus (mPOA) in context-appropriate vocal communication. During the breeding season, male songbirds sing primarily to attract females (sexually-motivated song) and to repel competitors (agonistically-motivated song). Past data link dopamine and D1 dopamine receptors in the mPOA to sexually-motivated but not agonistically-motivated song; however, direct effects of dopamine receptor manipulations in the mPOA on song have not been experimentally tested. Here we tested the hypothesis that D1 receptor stimulation in the mPOA selectively influences sexually-motivated male song and the possibility that the effects of D1 agonism differ at low and high doses. In a first study, breeding condition male European starlings received infusions of saline or a single dose of the D1 receptor agonist SKF 38393 on separate test days into mPOA or hypothalamic control areas. Stimulation of D1 receptors in mPOA triggered sexually-motivated but not agonistically-motivated song. A second study showed inverted-U shaped dose-response effects of the agonist such that low levels of sexually-motivated song were observed at low and high levels of D1 receptor activation. A third study showed that effects of the D1 agonist were blocked by the D1 receptor antagonist SCH 23390. These findings suggest that an optimal level of D1 dopamine receptor stimulation in mPOA is needed to facilitate sexually-motivated vocal production. The results support a central, context-specific role for the mPOA in vocal communication and more broadly demonstrate a complex, modulatory influence of D1 receptors in mPOA on sexually-motivated behavior.
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