Psychological stress enhances keloid development via stress hormone-induced abnormal cytokine profiles and inflammatory responses
Psychological stress enhances keloid development via stress hormone-induced abnormal cytokine profiles and inflammatory responses
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心理压力通过应激激素诱导的异常细胞因子谱和炎症反应促进瘢痕疙瘩的发展
DOI：
10.20517/2347-9264.2020.24
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Wei Liu
中科院分区：
文献类型：
--
作者：
Yating Yang;Xiaoli Wu;Wei Liu
瘢痕疙瘩是一种由于创面愈合过程异常而导致的纤维增生性疾病，它既会引起美容问题，也会导致功能障碍。遗传易感性、伤口创伤、异物反应、机械拉伸和免疫功能障碍是常见的危险因素，但机制仍不清楚，这给解决复发和耐药的临床问题留下了挑战。然而，瘢痕疙瘩和癌症之间相似的生长和代谢模式为未来探索瘢痕疙瘩的发病机制提供了独特的见解。心理应激已被证明与多种癌症的发生和耐药有关，但在瘢痕疙瘩中这方面的研究仍然较少。临床观察和已发表的研究已经注意到，持续应激在瘢痕疙瘩患者中很常见，在应激条件下，他们的症状往往会恶化。在对已发表的文献进行全面回顾之后，我们确定了三条信号通路，它们可能暗示应激激素可能通过激活肾上腺素能受体和免疫系统失调来影响瘢痕疙瘩的发病。因此，我们假设心理应激通过刺激纤维化、加重局部缺氧而成为瘢痕疙瘩形成的关键危险因素。
Keloid is a fibroproliferative disorder resulting from the abnormal wound healing process, and it causes both cosmetic concerns and functional disabilities. Genetic predisposition, wound trauma, foreign body reaction, mechanical stretch, and immune dysfunction are common risk factors, but there remain mechanisms unclarified, leaving challenges in addressing the clinical concerns of recurrence and resistance. However, similar patterns of growth and metabolism between keloids and cancers provide a unique insight into the future exploration of keloid pathogenesis. Psychological stress has been demonstrated to be involved in the development and drug resistance of multiple cancers, but this aspect remains less-explored in keloids. Clinical observations and published investigations have noticed that persistent stress is common among keloid patients and their symptoms tend to deteriorate under stressful conditions. Following a thorough review of the published literature, we have identified three signaling pathways that might imply how stress hormones are likely to influence the keloid pathogenesis via activating adrenergic receptors and dysregulating the immune system. Thus, we hypothesized that psychological stress would be a key risk factor for keloid development via stimulating fibrosis, aggravating local hypoxia, and
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DOI：
--
发表时间：
2002
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
B. Waldrop;Diana M. Mastalerz;M. Piascik;G. Post
通讯作者：
B. Waldrop;Diana M. Mastalerz;M. Piascik;G. Post
心理应激诱导外周血白细胞中白细胞介素 2 受体基因表达和白细胞介素 2 产生的调节。
影响因子：
--
作者：
Glaser,R;Kennedy,S;Lafuse,WP;Bonneau,RH;Speicher,C;Hillhouse,J;Kiecolt-Glaser,JK
通讯作者：
Kiecolt-Glaser,JK
影响因子：
--
作者：
Kiecolt-Glaser, JK;Loving, TJ;Glaser, R
通讯作者：
Glaser, R
影响因子：
--
作者：
Glaser, R;Robles, TF;Kiecolt-Glaser, JK
通讯作者：
Kiecolt-Glaser, JK
DOI：
10.1093/gerona/56.8.m477
发表时间：
2001-08-01
影响因子：
5.1
作者：
Glaser, R;MacCallum, RC;Kiecolt-Glaser, JK
通讯作者：
Kiecolt-Glaser, JK