Developmentally defined forebrain circuits regulate appetitive and aversive olfactory learning.
Developmentally defined forebrain circuits regulate appetitive and aversive olfactory learning.
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DOI：
10.1038/nn.4452
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发表时间：
2017-01
影响因子：
25
通讯作者：
Ghashghaei, H. Troy
中科院分区：
文献类型：
--
作者：
Muthusamy, Nagendran;Zhang, Xuying;Johnson, Caroline A.;Yadav, Prem N.;Ghashghaei, H. Troy
Postnatal and adult neurogenesis are region- and modality-specific, but the significance of developmentally distinct neuronal populations remains unclear. We demonstrate that chemogenetic inactivation of a subset of forebrain and olfactory neurons generated at birth disrupts responses to an aversive odor. In contrast, novel appetitive odor learning is sensitive to inactivation of adult born neurons, unveiling that developmentally defined sets of neurons may differentially participate in hedonic aspects of sensory learning.
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影响因子：
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作者：
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通讯作者：
Imayoshi I
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Ghyselinck, NB
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