Age-Related Variations of Rabbit Corneal Geometrical and Clinical Biomechanical Parameters.

Age-Related Variations of Rabbit Corneal Geometrical and Clinical Biomechanical Parameters.
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兔角膜几何和临床生物力学参数与年龄相关的变化

DOI:
10.1155/2017/3684971
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发表时间:
2017
影响因子:
--
通讯作者:
Li L
Li L
中科院分区:
生物学3区
文献类型:
--
作者:
Zhang H;Qin X;Cao X;Zhang D;Li L

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目的研究兔角膜临床生物力学参数(CCBP)和角膜几何参数随年龄的变化规律。方法选用3、7、12、18、24个月龄兔。用眼球反应分析仪(ORA)、光学相干断层扫描仪(OCT)和角膜测厚仪测量眼压(IOP):Goldmann相关眼压(IOPg)和角膜代偿性眼压(IOPcc);CCBP:角膜滞后(CH)和角膜阻力因子(CRF);角膜几何参数:角膜曲率半径(Ccr)和中央角膜厚度(CCT)。结果兔眼压在3~7月龄变化不大,7~18月龄显著下降,18~24月龄显著升高,CH和CRF随年龄增长而降低,CCT在7~18月龄升高,3~7月龄和18~24月龄下降,Ccr在3~18月龄呈上升趋势,18~24月龄显著下降。结论CH、CRF与年龄呈负相关。CCT、Ccr与年龄呈正相关。
Purpose To study the variations in corneal clinical biomechanical parameters (CCBP) and corneal geometrical parameters of rabbit in relation to age. Methods Rabbits aged 3, 7, 12, 18, and 24 months were enrolled. Each eye of the rabbits was tested with Ocular Response Analyzer (ORA), Optical Coherence Tomography (OCT), and Pachymeter to obtain the intraocular pressure (IOP): Goldmann-correlated IOP (IOPg) and Corneal Compensated Intraocular Pressure (IOPcc); CCBP: Corneal Hysteresis (CH) and Corneal Resistance Factor (CRF); corneal geometric parameters: corneal curvature radius (CCR) and central corneal thickness (CCT). Results The IOP of the rabbits changes slightly from 3 to 7 months of age, while it significantly decreases from 7 to 18 months of age and increases from 18 to 24 months of age; CH and CRF decrease with the increase of age; CCT increases from 7 to 18 months and decreases from 3 to 7 months of age and from 18 to 24 months of age; CCR presents an upward trend from 3 to 18 months and a significant decrease between 18 and 24 months of age. Conclusion CH and CRF are negatively correlated with age. CCT and CCR are positively correlated with age.
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