Spindle cell subtype of pulmonary clear cell tumor with prominent calcification and malignant potential.
Spindle cell subtype of pulmonary clear cell tumor with prominent calcification and malignant potential.
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具有显着钙化和恶性潜能的肺透明细胞瘤梭形细胞亚型
DOI：
10.1111/1759-7714.12457
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发表时间：
2017-09
期刊：
影响因子：
2.9
通讯作者：
Lin X
中科院分区：
文献类型：
--
作者：
Song Y;Chen F;Zhang C;Lin X
肺血管周围上皮样细胞瘤，又称透明细胞“糖”瘤，是一种罕见的由血管周围上皮样细胞引起的良性肿瘤。在此，我们报告一例49岁女性的梭形细胞亚型肺血管周围上皮样细胞瘤，具有明显的钙化和恶性潜能。组织学上，这种病变的显著特征是由于梭形细胞呈弥漫性排列，这是诊断的一个陷阱。然而，一些病变包含多边形肿瘤细胞，细胞质清晰丰富，周围有薄壁血管间隙。肿瘤的大小及其Ki‐67指数提示恶性潜能，钙化是另一个罕见的特征。免疫染色表明，肿瘤细胞不仅HMB‐45和Melan - A阳性，而且CD34和CD1a阳性。该肿瘤应与梭形细胞丰富的肿瘤如肉瘤、透明细胞癌或转移性肿瘤区分开来。本例患者在肺叶切除术后6个月存活，无肿瘤复发或转移。
Perivascular epithelioid cell tumor of the lung, also known as clear cell “sugar” tumor, is a rare benign tumor arising from perivascular epithelioid cells. Herein, we present a case of spindle cell subtype of pulmonary perivascular epithelioid cell tumor with prominent calcification and malignant potential in a 49‐year‐old woman. Histologically, the striking feature of this lesion was attributed to the presence of spindle cells arranged in a diffuse pattern, which is a pitfall for diagnosis. However, some of the lesion contained polygonal tumor cells with clear abundant cytoplasm surrounded by thin‐walled vascular spaces. The size of the tumor and its Ki‐67 index suggested malignant potential, and calcification was another rare characteristic. Immunostaining indicated that the tumor cells were positive not only for HMB‐45 and Melan A, but also for CD34 and CD1a. This tumor should be distinguished from tumors with rich spindle cells such as sarcoma, clear cell carcinoma, or metastatic tumors. The patient in this case was alive with no tumor recurrence or metastasis six months after lobectomy.
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影响因子：
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