Telocytes are the common cell of origin of both PEComas and GISTs: an evidence-supported hypothesis.
Telocytes are the common cell of origin of both PEComas and GISTs: an evidence-supported hypothesis.
复制标题
特细胞是 PEComas 和 GIST 的共同起源细胞：这是一个有证据支持的假设。
DOI：
10.1111/j.1582-4934.2011.01461.x
复制
发表时间：
2011-12
影响因子：
5.3
通讯作者：
Bussolati G
中科院分区：
文献类型：
--
作者：
Ardeleanu C;Bussolati G
我们提出的假设，端细胞可能是PEComas（血管周围上皮样细胞肿瘤）和GIST（胃肠道和胃肠道外间质瘤）的起源细胞。这一假设得到了来自文献的数据的支持，文献报道PEComas和GIST以及端细胞都有几种标记物的表达。这些数据由选定系列的原始免疫组织化学试验补充。具体而言：（1）PEComa的典型黑素瘤标志物（Melan A，MiTF）由相当大部分的GIST表达。一部分GIST也被发现对CD 63呈阳性，CD 63是一种最初在黑色素瘤中描述的四跨膜蛋白，并标记外来体。(2)绝大多数GIST特有的c-KIT（CD 117）可由PEComa（以及端细胞）表达。(3)端细胞中描述的标志物（CD 34、S-100、平滑肌肌动蛋白和血管内皮生长因子）在PEComa和GIST病例中报告为阳性。端细胞显示出独特的超微结构特征，具有薄的、延伸的端足，并且可能通过旁分泌以及脱落的囊泡和外泌体参与细胞间信号传导。这些细胞已在许多位置（空腔和非空腔器官）进行了描述，并可能显示出广泛的分化（和功能）潜力。总之，我们建议端细胞可能是共同的细胞起源的PEComas和GIST。
We advance the hypothesis that the telocyte might be the cell of origin of both PEComas (perivascular epithelioid cell tumours) and GISTs (gastro-intestinal and extra-gastrointestinal stromal tumours). The hypothesis is supported by data from the literature reporting that both PEComas and GISTs, as well as telocytes, share the expression of several markers. These data were supplemented by original immunohistochemical tests on selected series. Specifically: (1) Melanoma markers (Melan A, MiTF) typical of PEComas are expressed by a substantial fraction of GISTs. A fraction of GISTs was also found positive for CD63, a tetraspanin protein originally described in melanomas and marking exosomes. (2) c-KIT (CD117), proper of the vast majority of GISTs, can be expressed by PEComas (as well as by telocytes). (3) Markers described in telocytes (CD34, S-100, smooth muscle actin and vascular endothelial growth factor) have been reported as positive in cases of PEComas and GISTs. Telocytes show distinctive ultrastructural features with thin, extended, telopodes and are likely involved in inter-cellular signalling via paracrine secretion as well as by shed vesicles and exosomes. These cells have been described in many locations (cavitary and non-cavitary organs) and might display potentialities of a wide spectrum of differentiation (and function). In conclusion we propose that telocytes could be the common cells of origin for both PEComas and GISTs.
登录
查看更多内容
影响因子：
5.3
作者：
Cantarero Carmona I;Luesma Bartolomé MJ;Junquera Escribano C
通讯作者：
Junquera Escribano C
影响因子：
5.3
作者：
Kostin S
通讯作者：
Kostin S
影响因子：
3.6
作者：
Hinescu, Mihail E.;Gherghiceanu, Mihaela;Suciu, Laura;Popescu, Laurentiu M.
通讯作者：
Popescu, Laurentiu M.
影响因子：
5.3
作者：
Manole CG;Cismaşiu V;Gherghiceanu M;Popescu LM
通讯作者：
Popescu LM
影响因子：
2.2
作者：
Park, SH;Ro, JY;Lee, ES
通讯作者：
Lee, ES