Daytime napping, nighttime sleeping duration, and risk of hepatocellular carcinoma and liver disease-related mortality.
Daytime napping, nighttime sleeping duration, and risk of hepatocellular carcinoma and liver disease-related mortality.
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DOI：
10.1016/j.jhepr.2023.100819
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发表时间：
2023-10
期刊：
影响因子：
8.3
通讯作者：
Zhang, Xuehong
中科院分区：
文献类型：
--
作者：
Long, Lu;Zhao, Longgang;Petrick, Jessica L.;Liao, Linda M.;Huang, Tianyi;Hakim, Aaron;Yang, Wanshui;Campbell, Peter T.;Giovannucci, Edward;Mcglynn, Katherine A.;Zhang, Xuehong
睡眠时间与代谢功能障碍和慢性炎症有关，这可能有助于肝癌和慢性肝病（CLD）的发展。然而，睡眠或午睡时间与肝细胞癌（HCC）风险和CLD死亡率之间的关系知之甚少。我们在美国国立卫生研究院-美国退休人员协会（NIH-AARP）饮食与健康研究中跟踪了295，837人。我们研究了夜间睡眠时间和白天小睡时间与HCC发病率和CLD死亡率风险的关系。使用考克斯比例风险回归计算多变量风险比（HR）和95%置信区间（95% CI）。在中位随访时间15.5年后，共确定了357例HCC事件和578例CLD死亡。在调整混杂因素后，我们发现夜间睡眠时间与HCC的发病率呈U型关系（HR<5 vs. 7-8 h = 2.00，95% CI：1.22-3.26和HR≥9 vs. 7-8 h = 1.63，95% CI：1.04-2.65）和CLD死亡率（HR<5 vs. 7-8 h = 1.78，95% CI：1.18-2.69和HR≥9 vs. 7-8 h = 1.91，95% CI：1.35-2.70）。与不午睡相比，白天午睡与更高的HCC风险（HR≥1 vs.非午睡者= 1.46，95% CI：1.04-2.06）和更高的CLD死亡率（HR≥1 h vs.非午睡者= 1.54，95% CI：1.18-2.01）相关。我们观察到夜间睡眠与HCC和CLD死亡率的风险呈U型相关。此外，较长的日间小睡时间与HCC和CLD死亡的风险较高相关。我们的研究表明，对有肝癌风险或患有肝病的个体的临床随访应包括夜间和白天睡眠的信息。睡眠或午睡时间可能在肝癌和慢性肝病的发展中发挥作用，但对它们之间的关系知之甚少。此外，慢性肝病患者的睡眠模式异常可能会进一步促进肝病的发展，形成恶性循环。我们的研究表明，对有肝癌风险或患有肝病的个体进行临床随访应包括夜间和白天睡眠的信息，因为它们可能是肝病发展和进展的潜在重要因素。研究发现夜间睡眠与肝细胞癌（HCC）和慢性肝病（CLD）死亡率的风险呈U型关系，白天午睡时间越长，HCC和CLD死亡率的风险越高。在联合分析中，夜间睡眠7-8小时，白天小睡，比夜间睡眠7-8小时，没有午睡，患肝癌的风险更高。在亚组分析中，在不同的亚组中观察到睡眠时间与HCC风险和CLD死亡率的相似U形关联。
Sleep duration has been linked to metabolic dysfunction and chronic inflammation, which may contribute to the development of liver cancer and chronic liver disease (CLD). However, little is known about the relationship between sleep or napping duration and hepatocellular carcinoma (HCC) risk and CLD mortality. We followed 295,837 individuals in the National Institutes of Health-American Association of Retired Persons (NIH-AARP) Diet and Health Study. We examined the associations of nighttime sleep duration and daytime napping duration with risk of HCC incidence and CLD mortality. Cox proportional hazards regression was used to calculate multivariable hazard ratios (HRs) and 95% confidence intervals (95% CIs). A total of 357 incident HCC cases and 578 CLD deaths were identified after a median follow-up time of 15.5 years. After adjusting for confounder factors, we found U-shaped associations of nighttime sleep duration with the incidence of HCC (HR<5 vs. 7–8 h = 2.00, 95% CI: 1.22–3.26 and HR≥9 vs. 7–8 h = 1.63, 95% CI: 1.04–2.65) and CLD mortality (HR<5 vs. 7–8 h = 1.78, 95% CI: 1.18–2.69 and HR≥9 vs. 7–8 h = 1.91, 95% CI: 1.35–2.70). Daytime napping was associated with higher risk of HCC (HR≥1 vs. non-nappers = 1.46, 95% CI: 1.04–2.06) and higher CLD mortality (HR≥1 h vs. non-nappers = 1.54, 95% CI: 1.18–2.01) compared with no napping. We observed U-shaped associations for nighttime sleeping and risk of HCC and CLD mortality. Additionally, longer daytime napping duration was associated with higher risk of HCC and CLD death. Our study suggests that clinical follow up of individuals at risk for liver cancer or living with a liver disease should include information on nighttime and daytime sleep. Sleep or napping duration may play a role in the development of liver cancer and chronic liver disease, but little is known about the relationship between them. In addition, abnormal sleep patterns in patients with chronic liver disease may further promote the development of liver disease, creating a vicious cycle. Our study suggests that clinical follow up of individuals at risk for liver cancer or living with a liver disease should include information on nighttime and daytime sleep, as they can be potentially important factors in the development and progression of liver disease. U-shaped associations of nighttime sleeping with the risk of hepatocellular carcinoma (HCC) and chronic liver disease (CLD) mortality were found. Longer daytime napping duration was associated with higher risk of HCC and CLD mortality. In the joint analysis, 7–8 h of sleep at night with daytime napping had a higher risk of developing HCC than 7–8 h nighttime sleep without napping. In subgroup analyses, similar U-shaped associations of sleeping duration with risk of HCC and CLD mortality across different subgroups were observed.
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NIH-AARP饮食和健康研究队列中的睡眠持续时间和癌症。
影响因子：
3.7
作者：
Gu F;Xiao Q;Chu LW;Yu K;Matthews CE;Hsing AW;Caporaso NE
通讯作者：
Caporaso NE
影响因子：
2.5
作者：
Chen, Guo-Chong;Liu, Meng-Meng;Qin, Li-Qiang
通讯作者：
Qin, Li-Qiang
DOI：
10.1126/science.1198125
发表时间：
2011-03-11
期刊：
Science (New York, N.Y.)
影响因子：
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作者：
Feng D;Liu T;Sun Z;Bugge A;Mullican SE;Alenghat T;Liu XS;Lazar MA
通讯作者：
Lazar MA
影响因子：
4.3
作者：
Chou, Yu-Tsung;Cheng, Hsiang-Ju;Lu, Feng-Hwa
通讯作者：
Lu, Feng-Hwa
影响因子：
13.5
作者：
Birkenfeld, Andreas L.;Shulman, Gerald I.
通讯作者：
Shulman, Gerald I.