Flexible circuit mechanisms for context-dependent song sequencing.
Flexible circuit mechanisms for context-dependent song sequencing.
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DOI：
10.1038/s41586-023-06632-1
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发表时间：
2023-10
期刊：
影响因子：
64.8
通讯作者：
Murthy, Mala
中科院分区：
文献类型：
--
作者：
Roemschied, Frederic A.;Pacheco, Diego A.;Aragon, Max J.;Ireland, Elise C.;Li, Xinping;Thieringer, Kyle;Pang, Rich;Murthy, Mala
顺序行为，包括运动、伸手和发声，在不同的背景下会有不同的模式，使动物能够适应环境。背景信息如何塑造神经活动以灵活地改变动作模式还没有完全理解。以前的工作表明，这可以通过并联电机电路来实现，对上下文具有不同的敏感性。在这里，我们表明，一个单一的途径在两个制度依赖于最近的感觉历史。我们利用果蝇的歌曲生产系统来研究几种神经元类型在歌曲模式中的作用，近与远的雌性苍蝇。雄性果蝇在远离雌性果蝇的地方只唱出一种模式的“简单”歌曲序列，但在靠近雌性果蝇的地方唱出复杂的歌曲序列，包括模式之间的交替。我们发现腹神经索（VNC）回路是由驱动两种歌曲模式的节点之间的相互抑制和反弹兴奋性塑造的。简短的感觉输入到一个直接的大脑到VNC兴奋性通路驱动简单的歌曲远离女性，而长期的输入，使复杂的歌曲生产通过同时招聘的VNC电路的功能去抑制。因此，女性接近解锁电机电路动态在正确的情况下。我们构建了一个紧凑的电路模型，以证明所确定的机制足以复制自然的歌曲动态。这些结果突出了如何规范的电路图案可以结合起来，使电路的灵活性所需的动态通信。深入了解果蝇的歌曲生产系统的基本神经回路提供了使用歌曲模式的男性近与远的女性。
Sequenced behaviours, including locomotion, reaching and vocalization, are patterned differently in different contexts, enabling animals to adjust to their environments. How contextual information shapes neural activity to flexibly alter the patterning of actions is not fully understood. Previous work has indicated that this could be achieved via parallel motor circuits, with differing sensitivities to context. Here we demonstrate that a single pathway operates in two regimes dependent on recent sensory history. We leverage the Drosophila song production system to investigate the role of several neuron types in song patterning near versus far from the female fly. Male flies sing ‘simple’ trains of only one mode far from the female fly but complex song sequences comprising alternations between modes when near her. We find that ventral nerve cord (VNC) circuits are shaped by mutual inhibition and rebound excitability between nodes driving the two song modes. Brief sensory input to a direct brain-to-VNC excitatory pathway drives simple song far from the female, whereas prolonged input enables complex song production via simultaneous recruitment of functional disinhibition of VNC circuitry. Thus, female proximity unlocks motor circuit dynamics in the correct context. We construct a compact circuit model to demonstrate that the identified mechanisms suffice to replicate natural song dynamics. These results highlight how canonical circuit motifs can be combined to enable circuit flexibility required for dynamic communication. Insights into the underlying neuronal circuitry of the Drosophila song production system are provided using song patterning of males near versus far from the female.
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