T-Cell Mediated Immunity in Merkel Cell Carcinoma.
T-Cell Mediated Immunity in Merkel Cell Carcinoma.
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人们一直致力于探索病毒阳性和病毒阴性默克尔细胞癌的病理生理学基础。越来越多的研究强调了T细胞在这种罕见皮肤癌的发生、发展和清除中的作用。最近研究的最新总结探索T细胞介导的免疫默克尔细胞癌通知未来的研究方向以及免疫治疗的目标。默克尔细胞癌（MCC）是一种罕见的和经常致命的皮肤癌与神经内分泌的特点。MCC可以起源于MCC多瘤病毒（MCPyV）DNA的存在或可导致DNA突变的慢性紫外线（UV）暴露。MCC主要存在于身体暴露于阳光的区域，并且可以转移到区域淋巴结、肝、肺、骨和脑。年龄较大、皮肤较浅、有大量阳光照射史的人风险最高。先前的研究已经表明，含有大量肿瘤浸润性T细胞的肿瘤即使在不存在MCPyV DNA的情况下也具有有利的存活，这表明MCPyV感染增强了T细胞浸润。然而，其他因素也可能在宿主抗肿瘤反应中发挥作用。本文综述了肿瘤浸润淋巴细胞（TIL），主要是CD4+、CD8+和调节性T细胞（TCLs）对MCC病程的影响，包括它们在启动MCP γ V特异性免疫应答中的作用。此外，还讨论了MCC中与T细胞生物学相关的潜在研究途径以及相关的免疫治疗。
Efforts have been directed toward exploring the pathophysiology underlying virus-positive and virus-negative Merkel cell carcinoma. An increasing amount of research has underlined the role of T-cells in the initiation, progression, and clearance of this rare skin cancer. An updated summary of recent research exploring T-cell-mediated immunity in Merkel cell carcinoma informs future research directions as well as targets for immunotherapy. Merkel cell carcinoma (MCC) is a rare and frequently lethal skin cancer with neuroendocrine characteristics. MCC can originate from either the presence of MCC polyomavirus (MCPyV) DNA or chronic ultraviolet (UV) exposure that can cause DNA mutations. MCC is predominant in sun-exposed regions of the body and can metastasize to regional lymph nodes, liver, lungs, bone, and brain. Older, light-skinned individuals with a history of significant sun exposure are at the highest risk. Previous studies have shown that tumors containing a high number of tumor-infiltrating T-cells have favorable survival, even in the absence of MCPyV DNA, suggesting that MCPyV infection enhances T-cell infiltration. However, other factors may also play a role in the host antitumor response. Herein, we review the impact of tumor infiltrating lymphocytes (TILs), mainly the CD4+, CD8+, and regulatory T-cell (Tregs) responses on the course of MCC, including their role in initiating MCPyV-specific immune responses. Furthermore, potential research avenues related to T-cell biology in MCC, as well as relevant immunotherapies are discussed.
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DOI：
10.1038/nri3921
发表时间：
2015-12
期刊：
Nature reviews. Immunology
影响因子：
--
作者：
通讯作者：
--
影响因子：
78.8
作者：
Crusz, Shanthini M.;Balkwill, Frances R.
通讯作者：
Balkwill, Frances R.
影响因子：
2.8
作者：
Campillo-Navarro, Marcia;Leyva-Paredes, Kahiry;Chacon-Salinas, Rommel
通讯作者：
Chacon-Salinas, Rommel
影响因子：
9
作者：
Akimoto M;Hayashi JI;Nakae S;Saito H;Takenaga K
通讯作者：
Takenaga K
DOI：
10.3390/v13010061
发表时间：
2021-01-05
期刊：
Viruses
影响因子：
--
作者：
Prezioso C;Carletti R;Obregon F;Piacentini F;Manicone AM;Soda G;Moens U;Di Gioia C;Pietropaolo V
通讯作者：
Pietropaolo V