Increased prevalence of cardiovascular defects among 56,709 California twin pairs.
Increased prevalence of cardiovascular defects among 56,709 California twin pairs.
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DOI：
10.1002/ajmg.a.32745
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发表时间：
2009-05
影响因子：
2
通讯作者：
Shaw, G. M.
中科院分区：
文献类型：
--
作者：
Hardin, J.;Carmichael, S. L.;Selvin, S.;Lammer, E. J.;Shaw, G. M.
本研究比较了双胎和单胎婴儿心血管缺陷的患病率，并探讨了卵性（单卵和双卵）和母亲年龄（<35岁和≥35岁）对一致性的影响。从加州出生缺陷监测项目和加州生命统计局1983-2003年期间的出生和胎儿死亡记录中获得了有心血管缺陷的双胞胎和单胞胎婴儿（n=628对双胞胎和n=14,078例单胞胎）和无心血管缺陷的双胞胎和单胞胎婴儿（n=53,974对双胞胎和n=4,858,255例单胞胎）的数据。计算了16种先天性心血管疾病的患病率比（PR）（双胞胎/单胞胎的患病率）和大约95%的置信区间。Poisson回归技术使用对数线性模型来评估每个心血管类别内缺陷的一致性概率是否因合子性或母亲年龄而异。在所有16种心血管疾病中，双胞胎的患病率均高于单胞胎。与单胞胎相比，双胞胎中有7种心血管疾病的患病率至少是单胞胎的两倍。同性别双胞胎，作为单卵性的代表，与异性别双胞胎相比，心血管缺陷的患病率增加。同卵双胞胎的血流病变的一致性概率高于异卵双胞胎。我们的研究提供了证据表明，双胞胎比单胞胎与更多的心血管缺陷有关。在单卵双胞胎中观察到血流病变的一致性增加，这一观察结果与心血管缺陷家族性复发研究的结果一致。
This study compared the prevalence of cardiovascular defects in twin and singleton births and explored the influences of zygosity (monozygotic and dizygotic) and maternal age (<35 and ≥35 years of age) on concordance. Data on twin and singleton infants with (n=628 twin pairs and n=14,078 singletons) and without (n=53,974 twin pairs and n=4,858,255 singletons) cardiovascular defects were obtained from the California Birth Defects Monitoring Program and the California vital statistics birth and fetal death records during the period 1983-2003. Prevalence ratios (PR) (prevalence of twin/singleton) and approximate 95% confidence intervals were calculated for sixteen congenital cardiovascular categories. Poisson regression techniques using log-linear models were employed to assess whether the probability of concordance of defects within each cardiovascular category varied by zygosity or maternal age. An increased prevalence was observed in twins compared to singletons in all 16 cardiovascular categories. Seven of the cardiovascular categories had at least double the prevalence in twins compared to singletons. Like-sex twins, as a proxy of monozygosity, had an increased prevalence of cardiovascular defects compared to unlike sex twins. Probabilities of concordance for flow lesions were higher among monozygotic than dizygotic twins. Our study provides evidence that twinning is associated with more cardiovascular defects than singletons. Increased concordance for flow lesions in monozygotic twins was observed, an observation that is in agreement with findings from familial recurrence studies of cardiovascular defects.
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影响因子：
0.7
作者：
Lammer, EJ;Scholes, T;Abrams, L
通讯作者：
Abrams, L
DOI：
10.1016/s0735-1097(03)00853-2
发表时间：
2003-09-03
影响因子：
24
作者：
Gill, HK;Splitt, M;Simpson, JM
通讯作者：
Simpson, JM
DOI：
10.1001/archpedi.1989.02150240083023
发表时间：
1989-12-01
影响因子：
--
作者：
BERG, KA;ASTEMBORSKI, JA;FERENCZ, C
通讯作者：
FERENCZ, C
DOI：
10.1017/s0001566000007510
发表时间：
1984-01-01
期刊：
ACTA GENETICAE MEDICAE ET GEMELLOLOGIAE
影响因子：
--
作者：
BURN, J;CORNEY, G
通讯作者：
CORNEY, G
影响因子：
6.3
作者：
DOYLE, PE;BERAL, V;WALE, CJ
通讯作者：
WALE, CJ