Iron status of blood donors.
Iron status of blood donors.
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DOI：
10.1097/moh.0000000000000733
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发表时间：
2022-11-01
影响因子：
3.2
通讯作者：
Mast, Alan E.
中科院分区：
文献类型：
--
作者：
Spencer, Bryan R.;Mast, Alan E.
本文回顾了最近的研究，在献血者的铁缺乏症的患病率和重要性，并努力减轻it.Pre-menopause女性，青少年和高频捐助者是在高风险的捐赠引起的铁缺乏症，在高和低资源的设置。在献血人群中，铁储存与血红蛋白水平和低血红蛋白延迟相关的生理学得到了很好的阐明，但在没有贫血的情况下，由于铁损失而引起的临床效应很难确定。扩大采用铁蛋白检测正在改善供体管理，但可能会导致暂时供体丢失导致血液供应减少。随着计算模型的发展，个性化供体管理的潜力正在显现，这些模型预测个体献血间隔，旨在优化从每个供体采集的血液，同时最大限度地减少低血红蛋白去铁。减少缺铁的措施是可用的，可以在标准化或越来越个性化的基础上部署。血液中心、监管机构和献血者应继续评估解决这一问题的不同方法，以获得一种平衡的方法，既能维持足够的采血量，又能保障献血者的健康。
This review examines recent research on the prevalence and importance of iron deficiency in blood donors, and on efforts to mitigate it. Pre-menopausal females, teenagers, and high-frequency donors are at highest risk for donation-induced iron deficiency, in both high- and low-resource settings. The physiology relating iron stores to hemoglobin levels and low hemoglobin deferral is well elucidated in blood donor populations, yet the clinical effects attributable to iron loss in the absence of anemia are challenging to identify. Expanded adoption of ferritin testing is improving donor management but may cause decreases in the blood supply from temporary donor loss. The potential for personalized donor management is emerging with development of computational models that predict individual inter-donation intervals that aim to optimize blood collected from each donor while minimizing low hemoglobin deferrals. Measures to reduce iron deficiency are available that can be deployed on a standardized or, increasingly, personalized basis. Blood centers, regulators, and donors should continue to evaluate different approaches for addressing this problem, to obtain a balanced approach that is optimal for maintaining adequate collections while safeguarding donor health.
影响因子：
2.9
作者：
Spencer BR;Fox MP;Wise LA;Cable RG;Mast AE
通讯作者：
Mast AE
影响因子：
5.6
作者：
Earley EJ;Didriksen M;Spencer BR;Kiss JE;Erikstrup C;Pedersen OB;Sørensen E;Burgdorf KS;Kleinman SH;Mast AE;Busch MP;Ullum H;Page GP
通讯作者：
Page GP
影响因子：
2.9
作者：
Liu H;Burns RT;Spencer BR;Page GP;Mast AE;NHLBI Recipient Epidemiology Donor Evaluation Study (REDS)-III
通讯作者：
NHLBI Recipient Epidemiology Donor Evaluation Study (REDS)-III