Path integration in place cells of developing rats.
Path integration in place cells of developing rats.
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DOI：
10.1073/pnas.1719054115
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发表时间：
2018-02-13
影响因子：
11.1
通讯作者：
Moser MB
中科院分区：
文献类型：
--
作者：
Bjerknes TL;Dagslott NC;Moser EI;Moser MB
哺乳动物大脑中的神经元专门代表动物在环境中的位置。海马体中的位置细胞编码位置，而内侧内嗅皮质中的网格细胞（一个突触之外）也表达有关动物移动的距离和方向的信息。在这项研究中，我们发现，在 2.5-3 周龄的幼鼠中，位置细胞具有发射场，其位置取决于行进的距离，尽管这个年龄的网格场尚未成熟。结果表明，在缺乏完全成熟的网格模式的情况下，可以根据自运动引起的距离信息生成位置场。海马体中的位置细胞和内侧内嗅皮层中的网格细胞依赖于自我运动信息和路径整合来进行空间受限的放电。幼鼠在出生后 2.5 周左右离开巢穴时即可观察到位置细胞。相比之下，网格细胞的规则间隔放电仅在断奶后第四周期间出现。在本研究中，我们试图确定位置细胞是否能够在网格细胞系统成熟之前整合自运动信息。断奶前、断奶后和成年大鼠从起始墙到线性轨道末端的盒子进行连续试验时，在 200 厘米的线性轨道上记录位置细胞。起始墙的位置在试验序列的中间发生了改变。当在完全黑暗中进行记录时，无论动物的年龄如何，将细胞保持在距起始墙固定距离的区域。当灯光亮起时，位置场主要由外部地标决定，除了赛道的一开始。在幼年和成年动物中都观察到了这种转变。结果表明，断奶前的大鼠能够在网格细胞系统完全成熟之前根据自我运动的信息计算距离。
The mammalian brain has neurons that specifically represent the animal’s location in the environment. Place cells in the hippocampus encode position, whereas grid cells in the medial entorhinal cortex, one synapse away, also express information about the distance and direction that the animal is moving. In this study, we show that, in 2.5–3-wk-old rat pups, place cells have firing fields whose positions depend on distance travelled, despite the immature state of grid fields at this age. The results suggest that place fields can be generated from self-motion–induced distance information in the absence of fully matured grid patterns. Place cells in the hippocampus and grid cells in the medial entorhinal cortex rely on self-motion information and path integration for spatially confined firing. Place cells can be observed in young rats as soon as they leave their nest at around 2.5 wk of postnatal life. In contrast, the regularly spaced firing of grid cells develops only after weaning, during the fourth week. In the present study, we sought to determine whether place cells are able to integrate self-motion information before maturation of the grid-cell system. Place cells were recorded on a 200-cm linear track while preweaning, postweaning, and adult rats ran on successive trials from a start wall to a box at the end of a linear track. The position of the start wall was altered in the middle of the trial sequence. When recordings were made in complete darkness, place cells maintained fields at a fixed distance from the start wall regardless of the age of the animal. When lights were on, place fields were determined primarily by external landmarks, except at the very beginning of the track. This shift was observed in both young and adult animals. The results suggest that preweaning rats are able to calculate distances based on information from self-motion before the grid-cell system has matured to its full extent.
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影响因子：
5.3
作者：
Resnik, Evgeny;McFarland, James M.;Mehta, Mayank R.
通讯作者：
Mehta, Mayank R.
影响因子：
64.5
作者：
Acharya, Lavanya;Aghajan, Zahra M.;Mehta, Mayank R.
通讯作者：
Mehta, Mayank R.
影响因子：
16.2
作者：
Bjerknes, Tale L.;Moser, Edvard I.;Moser, May-Britt
通讯作者：
Moser, May-Britt
大鼠海马中内部生成的细胞组装序列。
影响因子：
56.9
作者：
Pastalkova, Eva;Itskov, Vladimir;Amarasingham, Asohan;Buzsaki, Gyoergy
通讯作者：
Buzsaki, Gyoergy
影响因子：
56.9
作者：
Langston, Rosamund F.;Ainge, James A.;Moser, May-Britt
通讯作者：
Moser, May-Britt