Effects of individual ozone exposure on lung function in the elderly: a cross-sectional study in China

Effects of individual ozone exposure on lung function in the elderly: a cross-sectional study in China
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个体臭氧暴露对老年人肺功能的影响:中国的一项横断面研究

DOI:
10.1007/s11356-019-04324-w
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发表时间:
2019-02
影响因子:
5.8
通讯作者:
Xu Yan
Xu Yan
中科院分区:
环境科学与生态学3区
文献类型:
--
作者:
Zhang Jiayao;Sun Hong;Chen Qi;Gu Jie;Ding Zhen;Xu Yan

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本研究的目的是评估个人臭氧(O3)暴露对老年人呼吸系统的急性健康影响。共有40名不吸烟的老年志愿者完成了个人24小时的O3和细颗粒物(PM2.5)的测量。为了评估健康影响,我们测量了呼出气冷凝液(EBC)中的肺功能和五种炎症生物标志物,包括白细胞介素-2(IL-2)、干扰素-γ(IFN-γ)、前列腺素E2(PGE 2)和肿瘤坏死因子α/β(TNFα/β)。在调整PM2.5、BMI和性别作为混杂因素后,我们使用广义相加模型分析O3与这些健康效应之间的关联。结果发现,O3与用力肺活量(FVC)或第一秒用力呼气容积(FEV 1)呈负相关。O3每增加10 μg/m3,FVC和FEV 1分别降低0.13 L(95%CI 0.01,0.26)和0.11 L(95%CI 0.02,0.20)。O3与EBC生物标志物之间无统计学意义。结果表明,个体24小时O3暴露与老年人肺功能下降有关。
The aim of this study was to assess the acute health effects of individual ozone (O3) exposure on the respiratory system in the elderly. A total of 40 non-smoking elderly volunteers completed personal 24 h of measurement for O3and fine particulate matter (PM2.5). To assess health effects, we measured the pulmonary function and five inflammatory biomarkers in exhaled breath condensate (EBC), including interleukin-2 (IL-2), interferon-γ (IFN-γ), prostaglandin E2(PGE2), and tumor necrosis factor α/β (TNFα/β). We used the generalized additive model to analyze the association between O3and these health effects, after adjusting PM2.5, BMI, and sex as confounders. As a result, we found a negative correlation between O3and forced vital capacity (FVC) or forced expiratory volume-one second (FEV1). With the increasing of O3by 10 μg/m3, FVC and FEV1 decreased by 0.13 L (95% CI 0.01, 0.26) and 0.11 L (95% CI 0.02, 0.20), respectively. We found no statistical significance between O3and biomarkers in EBC. The results suggested that individual 24-h O3exposure was associated with decreased pulmonary function in the elderly.
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发表时间: 2014-07-10
影响因子: 3.9
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影响因子: 1.8
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