Acute effects of air pollutants on pulmonary function among students: a panel study in an isolated island.
Acute effects of air pollutants on pulmonary function among students: a panel study in an isolated island.
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DOI：
10.1186/s12199-017-0646-3
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发表时间：
2017-04-04
影响因子：
4.7
通讯作者：
Shima M
中科院分区：
文献类型：
--
作者：
Yoda Y;Takagi H;Wakamatsu J;Ito T;Nakatsubo R;Horie Y;Hiraki T;Shima M
许多关于空气污染物对健康影响的流行病学研究都是在工厂和汽车等主要污染源的地区进行的。然而，在没有主要污染源的地区，空气污染物对健康的影响仍不清楚。本研究调查了无主要人工污染源的孤岛环境空气污染对健康学生肺功能的急性影响。在日本濑户内海的一个孤岛上上学的43名健康受试者进行了一项小组研究。我们于2014年5月每天早晨测量1秒用力呼气量（FEV 1）和呼气峰流速（PEF），持续约1个月。测量了直径≤ 2.5 μm的颗粒物（PM2.5）、直径在2.5和10 μm之间的颗粒物（PM10-2.5）、黑碳（BC）、臭氧（O3）和二氧化氮（NO2）的环境浓度。使用混合效应模型分析空气污染物浓度与肺功能之间的关系。FEV 1降低与BC浓度显著相关（-27.28 mL [95%置信区间（CI）：-54.10，-0.46]，四分位距（IQR）增加0.23 μg/m3）。PEF的降低与室内O3浓度显著相关（IQR增加11 ppb时为−8.03 L/min [95% CI：−13.02，−3.03]）。在有过敏史的受试者中，PM2.5浓度升高与FEV 1降低显著相关。在有哮喘史的受试者中，观察到室内O3浓度与肺功能之间呈负相关。我们的研究结果表明，BC和O3浓度的增加有急性肺功能的学生在一个孤立的岛屿没有主要的人工空气污染源。本文的在线版本（doi：10.1186/s12199-017-0646-3）包含补充材料，可供授权用户使用。
Many epidemiological studies on the health effects of air pollutants have been carried out in regions with major sources such as factories and automobiles. However, the health effects of air pollutants in regions without major sources remain unclear. This study investigated the acute effects of ambient air pollution on pulmonary function among healthy students in an isolated island without major artificial sources of air pollutants. A panel study was conducted of 43 healthy subjects who attended a school in an isolated island in the Seto Inland Sea, Japan. We measured the forced expiratory volume in 1 s (FEV1) and peak expiratory flow (PEF) every morning for about 1 month in May 2014. Ambient concentrations of particulate matter ≤ 2.5 μm in diameter (PM2.5), particulate matter between 2.5 and 10 μm in diameter (PM10-2.5), black carbon (BC), ozone (O3), and nitrogen dioxide (NO2) were measured. The associations between the concentrations of air pollutants and pulmonary function were analyzed using mixed-effects models. A decrease in FEV1 was significantly associated with BC concentrations (−27.28 mL [95%confidence interval (CI):−54.10,−0.46] for an interquartile range (IQR) increase of 0.23 μg/m3). The decrease in PEF was significantly associated with indoor O3 concentrations (−8.03 L/min [95% CI:−13.02,−3.03] for an IQR increase of 11 ppb). Among subjects with a history of allergy, an increase in PM2.5 concentrations was significantly associated with low FEV1. In subjects with a history of asthma, an inverse association between the indoor O3 concentration and pulmonary function was observed. Our results demonstrate that increases in BC and O3 concentrations have acute effects on the pulmonary function among students in an isolated island without major artificial sources of air pollutants. The online version of this article (doi:10.1186/s12199-017-0646-3) contains supplementary material, which is available to authorized users.
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影响因子：
10.4
作者：
Patel MM;Chillrud SN;Correa JC;Hazi Y;Feinberg M;Kc D;Prakash S;Ross JM;Levy D;Kinney PL
通讯作者：
Kinney PL
影响因子：
8.3
作者：
Patel, Molini M.;Chillrud, Steven N.;Deepti, K. C.;Ross, James M.;Kinney, Patrick L.
通讯作者：
Kinney, Patrick L.
影响因子：
10.4
作者：
Koenig, J Q;Jansen, K;Mar, T F;Lumley, T;Kaufman, J;Trenga, C A;Sullivan, J;Liu, L-J S;Shapiro, G G;Larson, T V
通讯作者：
Larson, T V
影响因子：
5.1
作者：
Carbone, U.;Montuori, P.;Triassi, M.
通讯作者：
Triassi, M.
DOI：
10.1183/09031936.00081410
发表时间：
2011-05
期刊：
The European respiratory journal
影响因子：
--
作者：
Berhane K;Zhang Y;Linn WS;Rappaport EB;Bastain TM;Salam MT;Islam T;Lurmann F;Gilliland FD
通讯作者：
Gilliland FD