Non-contrast estimation of diffuse myocardial fibrosis with dual energy CT: A phantom study.
Non-contrast estimation of diffuse myocardial fibrosis with dual energy CT: A phantom study.
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双重能量CT的弥漫性心肌纤维化的非对比度估计：一项幻影研究。
DOI：
10.1016/j.jcct.2017.12.002
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发表时间：
2018-01
影响因子：
5.4
通讯作者：
Raman SV
中科院分区：
文献类型：
--
作者：
Kumar V;McElhanon KE;Min JK;He X;Xu Z;Beck EX;Simonetti OP;Weisleder N;Raman SV
弥漫性心肌纤维化的评估目前是通过组织病理学或心脏磁共振完成的，弥漫性心肌纤维化是各种心脏病患者发生心力衰竭和心律失常等不良事件的基础。我们试图开发一种非造影剂方法，利用模体和合适的小动物模型中的双能量计算机断层扫描(DECT)来估计弥漫性心肌纤维化的数量。模体由匀浆的牛心肌和不同数量的1型胶原组成。15只小鼠分别接受了5周或8周的假手术、不手术或横动脉缩窄(TAC)，以产生中度或重度纤维化。体模和体外小鼠心脏在单一来源上成像，DECT扫描仪配备KVP开关。在40~140keV的能量下重建单色图像。对单能量(70keV)图像和多能量重建图像的平均心肌CT数进行线性判别分析(LDA)。使用多能量CT/LDA方法与单能量CT/LDA方法相比，在模体(80.0%比70.0%)和小鼠(93.3%比33.3%)中，心肌纤维化严重程度的分类更准确。与单一的基于能量的方法相比，具有多能量分析的DECT心肌成像可以更好地对心肌纤维化严重程度进行分类。在模型和动物模型中，非对比DECT可以准确和非侵入性地估计弥漫性心肌纤维化的程度。这些数据支持进一步评估这种方法在活体心肌纤维化评估中的作用。
Estimation of diffuse myocardial fibrosis, substrate for adverse events such as heart failure and arrhythmias in patients with various cardiac disorders, is presently done by histopathology or cardiac magnetic resonance. We sought to develop a non-contrast method to estimate the amount of diffuse myocardial fibrosis leveraging dual energy computed tomography (DECT) in phantoms and a suitable small animal model. Phantoms consisted of homogenized bovine myocardium with varying amounts of type 1 collagen. Fifteen mice underwent sham surgery, no procedure, or transverse aortic constriction (TAC) for 5 or 8 weeks to produce moderate or severe fibrosis, respectively. Phantoms and ex vivo mouse hearts were imaged on a single source, DECT scanner equipped with kVp switching. Monochromatic images were reconstructed at 40 to 140 keV. Linear discriminant analysis (LDA) was performed on mean myocardial CT numbers derived from single energy (70 keV) images as well as images reconstructed across multiple energies. Classification of myocardial fibrosis severity as low, moderate or severe was more often correct using the multi-energy CT/LDA approach vs. single energy CT/LDA in both phantoms (80.0% vs. 70.0%) and mice (93.3% vs. 33.3%). DECT myocardial imaging with multi-energy analysis better classifies myocardial fibrosis severity compared to a single energy-based approach. Non-contrast DECT can accurately and non-invasively estimate the extent of diffuse myocardial fibrosis in phantom and animal models. These data support further evaluation of this approach for in vivo myocardial fibrosis estimation.
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影响因子：
19.7
作者：
Nacif, Marcelo Souto;Kawel, Nadine;Bluemke, David A.
通讯作者：
Bluemke, David A.
T1 映射测量心肌纤维化的组织学验证：系统评价和荟萃分析
DOI：
10.1186/s12968-016-0313-7
发表时间：
2016-12-12
期刊：
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance
影响因子：
--
作者：
Diao KY;Yang ZG;Xu HY;Liu X;Zhang Q;Shi K;Jiang L;Xie LJ;Wen LY;Guo YK
通讯作者：
Guo YK
影响因子：
24
作者：
Mewton, Nathan;Liu, Chia Ying;Croisille, Pierre;Bluemke, David;Lima, Joao A. C.
通讯作者：
Lima, Joao A. C.
影响因子：
120.7
作者：
Gulati, Ankur;Jabbour, Andrew;Prasad, Sanjay K.
通讯作者：
Prasad, Sanjay K.
影响因子：
19.7
作者：
Bandula, Steve;White, Steven K.;Moon, James C.
通讯作者：
Moon, James C.