Comparison of psychophysical, electrophysiological, and fMRI assessment of visual contrast responses in patients with schizophrenia.
Comparison of psychophysical, electrophysiological, and fMRI assessment of visual contrast responses in patients with schizophrenia.
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DOI：
10.1016/j.neuroimage.2012.11.019
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发表时间：
2013-02-15
期刊：
影响因子：
5.7
通讯作者：
Butler PD
中科院分区：
文献类型：
--
作者：
Calderone DJ;Martinez A;Zemon V;Hoptman MJ;Hu G;Watkins JE;Javitt DC;Butler PD
NIMH 赞助的改善精神分裂症认知的认知神经科学治疗研究 (CNTRICS) 小组已将感知确定为评估精神分裂症患者认知缺陷的有用领域。从稳态视觉诱发电位 (ssVEP) 记录中得出的对比增益的具体测量结果表明，精神分裂症患者的视觉通路存在神经缺陷。对比敏感度的心理物理测量也显示这些患者的功能丧失。在当前的研究中，功能磁共振成像 (fMRI) 与 ssVEP 和对比敏感度测试结合使用，以阐明这些缺陷的神经基础。在功能磁共振成像扫描过程中，参与者观察到：1）在个体检测阈值对比度和高对比度下，在心理物理学对比敏感度任务中使用相同的低和高空间频率刺激； 2）与 ssVEP 范式中使用的刺激相同，其设计偏向于大细胞或细细胞视觉通路。在心理物理任务中，患者在两个空间频率下的对比敏感度均表现出显着受损，但在磁体中测试的低对比度和高对比度下，枕叶激活体积降低，但不是更高的空间频率。正如预期的那样，患者在大细胞偏向的 ssVEP 条件下表现出选择性缺陷。然而，枕叶功能磁共振成像反应表明，各组间大细胞和小细胞偏向刺激具有相同的一般模式。这些结果表明功能磁共振成像测量和心理物理学/ssVEP 测量之间存在分离。后面这些措施似乎对于此处探讨的对比缺陷的功能评估具有更大的价值。
Perception has been identified by the NIMH-sponsored Cognitive Neuroscience Treatment Research to Improve Cognition in Schizophrenia (CNTRICS) group as a useful domain for assessing cognitive deficits in patients with schizophrenia. Specific measures of contrast gain derived from recordings of steady-state visual evoked potentials (ssVEP) have demonstrated neural deficits within the visual pathways of patients with schizophrenia. Psychophysical measures of contrast sensitivity have also shown functional loss in these patients. In the current study, functional magnetic resonance imaging (fMRI) was used in conjunction with ssVEP and contrast sensitivity testing to elucidate the neural underpinnings of these deficits. During fMRI scanning, participants viewed 1) the same low and higher spatial frequency stimuli used in the psychophysical contrast sensitivity task, at both individual detection threshold contrast and at a high contrast; and 2) the same stimuli used in the ssVEP paradigm, which were designed to be biased toward either the magnocellular or parvocellular visual pathway. Patients showed significant impairment in contrast sensitivity at both spatial frequencies in the psychophysical task, but showed reduced occipital activation volume for low, but not higher, spatial frequency at the low and high contrasts tested in the magnet. As expected, patients exhibited selective deficits under the magnocellular-biased ssVEP condition. However, occipital lobe fMRI responses demonstrated the same general pattern for magnocellular- and parvocellular-biased stimuli across groups. These results indicate dissociation between the fMRI measures and the psychophysical/ssVEP measures. These latter measures appear to have greater value for the functional assessment of the contrast deficits explored here.
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