Mediterranean diet score is associated with greater allocentric processing in the EPAD LCS cohort: A comparative analysis by biogeographical region.
Mediterranean diet score is associated with greater allocentric processing in the EPAD LCS cohort: A comparative analysis by biogeographical region.
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DOI：
10.3389/fragi.2022.1012598
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发表时间：
2022
影响因子：
--
通讯作者：
Muniz-Terrera, Graciela
中科院分区：
文献类型：
--
作者：
Gregory, Sarah;Ritchie, Craig W.;Ritchie, Karen;Shannon, Oliver;Stevenson, Emma J.;Muniz-Terrera, Graciela
背景：坚持地中海饮食（MedDiet），一种主要以植物为基础的饮食模式，与降低痴呆发病率有关。大部分研究都集中在阿尔茨海默病（AD）痴呆和轻度认知障碍（MCI）上，很少有研究关注预防MCI和AD痴呆的临床前症状沉默阶段。尽管在全球范围内进行的研究有证据，但没有研究在一个队列中比较MedDiet在地中海地区内外的效果。方法：我们的研究探讨了MedDiet与泛欧EPAD LCS认知之间的横断面和纵向关联，比较了生活在地中海地区内外的人群（按欧盟生物地理定义分类）。在获得MEDAS评分来量化MedDiet的依从性后，我们使用线性回归和线性混合效应模型来测试MEDAS评分与四山测试（FMT）和神经心理状态评估可重复电池（RBANS）测量的认知功能之间的关联。我们还计算了MEDAS连续评分和PYRAMID评分，以提供MedDiet依从性的替代指标。结果：纳入1826例受试者，平均年龄65.69（±7.42）岁，女性居多（56.2%），有家族病史（65.8%），少数APOEε4携带者（38.9%）。较高的MEDAS分数与较好的FMT表现相关，无论是横向（n = 1,144， ß： - 0.11, SE: 0.04, p = 0.007）还是纵向（斜率：0.10,95% CI: 0.04 - 0.17, p: 0.002）。在横断面分析中，地中海地区的影响略大，纵向影响更强。在探索性分析中，MEDAS和FMT评分之间的关联仅在女性参与者中可见。一项不包括图卢兹和佩鲁贾的敏感性分析发现，较高的MEDAS和MEDAS连续得分，以及一些RBANS总分和指数得分之间存在显著关联。图卢兹和佩鲁贾是靠近生物地理区域但不在生物地理区域内的城市。结论：MedDiet依从性与更好的FMT评分相关，从纵向数据来看，地中海地区的效果最为明显。我们的敏感性分析表明，坚持MedDiet有更广泛的认知益处。这项研究强调了进一步探索MedDiet对谁以及对什么大脑健康结果有益的必要性。这一证据将确定生命过程中的一个机会窗口，以最大限度地发挥效益，并更好地为公共卫生运动和患者层面的干预提供信息。
Background: Adherence to the Mediterranean diet (MedDiet), a primarily plant-based eating pattern, has been associated with lower dementia incidence. Much of the research has focused on Alzheimer’s disease (AD) dementia and mild cognitive impairment (MCI), with less research looking at the preclinical symptomatically silent stages that pre-empt MCI and AD dementia. Although there is evidence from studies conducted globally, no studies have compared the effects of the MedDiet within and outside of the Mediterranean region in one cohort. Methods: Our study explored cross-sectional and longitudinal associations between MedDiet and cognition in the pan-European EPAD LCS, comparing those living within and outside of the Mediterranean region (as classified by European Union biogeographical definitions). After deriving MEDAS scores to quantify adherence to the MedDiet, we used linear regression and linear mixed effects models to test for associations between the MEDAS score and cognitive function measured by the Four Mountains Test (FMT) and the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). We additionally calculated MEDAS continuous and PYRAMID scores to provide alternative measures of MedDiet adherence. Results: We included 1826 participants, mean age 65.69 (±7.42) years, majority female (56.2%) with family history (65.8%) and minority APOEε4 carriers (38.9%). Higher MEDAS scores were associated with better performance on the FMT both cross-sectionally (n = 1,144, ß: −0.11, SE: 0.04, p = 0.007) and longitudinally (slope: 0.10, 95% CI: 0.04–0.17, p: 0.002). The effect was marginally greater in the Mediterranean region in the cross-sectional analysis, with a stronger effect emerging longitudinally. In exploratory analyses, the association between MEDAS and FMT scores was only seen in female participants. A sensitivity analysis excluding Toulouse and Perugia, as cities near, but not within, the biogeographical region, found significant associations between higher MEDAS and MEDAS continuous scores, and a number of RBANS total and index scores. Conclusion: MedDiet adherence is associated with better FMT scores, with effects seen most strongly in the Mediterranean region from longitudinal data. Our sensitivity analysis suggested a more global cognitive benefit of MedDiet adherence. This study highlights the need to further explore for whom and for what brain health outcomes the MedDiet confers benefit. This evidence would identify a window of opportunity in the life-course to maximise the benefit and better inform public health campaigns and patient-level interventions.
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影响因子：
14
作者：
Hoscheidt, Siobhan;Sanderlin, Ashley H.;Baker, Laura D.;Jung, Youngkyoo;Lockhart, Samuel;Kellar, Derek;Whitlow, Christopher;Hanson, Angela J.;Friedman, Seth;Register, Thomas;Leverenz, James B.;Craft, Suzanne
通讯作者：
Craft, Suzanne
影响因子：
11
作者：
Martinez-Lapiscina, Elena H.;Clavero, Pedro;Martinez-Gonzalez, Miguel A.
通讯作者：
Martinez-Gonzalez, Miguel A.
影响因子：
25
作者：
Khan, Usman A.;Liu, Li;Provenzano, Frank A.;Berman, Diego E.;Profaci, Caterina P.;Sloan, Richard;Mayeux, Richard;Duff, Karen E.;Small, Scott A.
通讯作者：
Small, Scott A.
影响因子：
2.5
作者：
Chen, Karren H. M.;Chuah, Lisa Y. M.;Chee, Michael W. L.
通讯作者：
Chee, Michael W. L.
影响因子：
13.8
作者：
Moustafa, Bayan;Trifan, Gabriela;Isasi, Carmen R.;Lipton, Richard B.;Sotres-Alvarez, Daniela;Cai, Jianwen;Tarraf, Wassim;Stickel, Ariana;Mattei, Josiemer;Talavera, Gregory A.;Daviglus, Martha L.;Gonzalez, Hector M.;Testai, Fernando D.
通讯作者：
Testai, Fernando D.