Adherence to Mediterranean diet and health status: meta-analysis.
Adherence to Mediterranean diet and health status: meta-analysis.
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DOI：
10.1136/bmj.a1344
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发表时间：
2008-09-11
期刊：
影响因子：
--
通讯作者：
Casini A
中科院分区：
文献类型：
--
作者：
Sofi F;Cesari F;Abbate R;Gensini GF;Casini A
目的系统回顾所有前瞻性队列研究，这些研究分析了在初级预防环境中坚持地中海饮食、死亡率和慢性病发病率之间的关系。前瞻性队列研究的荟萃分析。数据来源PubMed、Embase、Web of Science和Cochrane Central Register of Controlled Trials中1966年至2008年6月30日的英文和非英文出版物。研究回顾了前瞻性分析坚持地中海饮食、死亡率和发病率之间关系的研究；纳入了12项研究，共计1574299名受试者，随访时间从3年到18年不等。结果8个队列（514 816名受试者和33 576例死亡）的累积分析评估了与坚持地中海饮食相关的总死亡率，结果显示，坚持评分增加2分与死亡率降低显著相关（合并相对风险0.91,95%置信区间0.89至0.94）。同样，分析显示，更坚持地中海饮食对心血管死亡率（综合相对风险0.91,0.87至0.95）、癌症发病率或死亡率（0.94,0.92至0.96）、帕金森氏病和阿尔茨海默病的发病率（0.87,0.80至0.96）有有益作用。结论：更坚持地中海饮食与健康状况的显著改善有关，如总死亡率（9%）、心血管疾病死亡率（9%）、癌症发病率或死亡率（6%）以及帕金森病和阿尔茨海默病发病率（13%）的显著降低。这些结果似乎与公共卫生具有临床相关性，特别是鼓励地中海式饮食模式用于主要慢性疾病的初级预防。
Objective To systematically review all the prospective cohort studies that have analysed the relation between adherence to a Mediterranean diet, mortality, and incidence of chronic diseases in a primary prevention setting. Design Meta-analysis of prospective cohort studies. Data sources English and non-English publications in PubMed, Embase, Web of Science, and the Cochrane Central Register of Controlled Trials from 1966 to 30 June 2008. Studies reviewed Studies that analysed prospectively the association between adherence to a Mediterranean diet, mortality, and incidence of diseases; 12 studies, with a total of 1 574 299 subjects followed for a time ranging from three to 18 years were included. Results The cumulative analysis among eight cohorts (514 816 subjects and 33 576 deaths) evaluating overall mortality in relation to adherence to a Mediterranean diet showed that a two point increase in the adherence score was significantly associated with a reduced risk of mortality (pooled relative risk 0.91, 95% confidence interval 0.89 to 0.94). Likewise, the analyses showed a beneficial role for greater adherence to a Mediterranean diet on cardiovascular mortality (pooled relative risk 0.91, 0.87 to 0.95), incidence of or mortality from cancer (0.94, 0.92 to 0.96), and incidence of Parkinson’s disease and Alzheimer’s disease (0.87, 0.80 to 0.96). Conclusions Greater adherence to a Mediterranean diet is associated with a significant improvement in health status, as seen by a significant reduction in overall mortality (9%), mortality from cardiovascular diseases (9%), incidence of or mortality from cancer (6%), and incidence of Parkinson’s disease and Alzheimer’s disease (13%). These results seem to be clinically relevant for public health, in particular for encouraging a Mediterranean-like dietary pattern for primary prevention of major chronic diseases.
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影响因子：
158.5
作者：
KROMHOUT, D;BOSSCHIETER, EB;COULANDER, CD
通讯作者：
COULANDER, CD
影响因子：
7.1
作者：
WILLETT, WC;SACKS, F;TRICHOPOULOS, D
通讯作者：
TRICHOPOULOS, D
影响因子：
15.8
作者：
Genkinger, Jeanine M.;Koushik, Anita
通讯作者：
Koushik, Anita
影响因子：
37.8
作者：
de Lorgeril, M;Salen, P;Mamelle, N
通讯作者：
Mamelle, N
影响因子：
3.2
作者：
Bach, A;Serra-Majem, L;Obrador, B
通讯作者：
Obrador, B