Glycosaminoglycans in Tissue Engineering: A Review.

Glycosaminoglycans in Tissue Engineering: A Review.
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DOI:
10.3390/biom11010029
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发表时间:
2020-12-29
期刊:
影响因子:
5.5
通讯作者:
Panitch A
Panitch A
中科院分区:
生物学2区
文献类型:
--
作者:
Sodhi H;Panitch A

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糖胺聚糖是细胞外基质的天然成分,可驱动细胞行为并控制细胞周围的微环境,使其成为多种疾病的有希望的治疗靶点。最近的研究表明,重演细胞与细胞外基质的相互作用是组织工程的关键,其目的是模仿和再生内源性组织。正因为如此,在工程组织中掺入糖胺聚糖以驱动干细胞命运并促进细胞增殖已获得越来越多的关注。本文综述了糖胺聚糖在组织工程中的作用及其在组织工程中应用的最新进展。我们还评估了在这个利基研究的总体趋势,并提供洞察其未来的方向。
Glycosaminoglycans are native components of the extracellular matrix that drive cell behavior and control the microenvironment surrounding cells, making them promising therapeutic targets for a myriad of diseases. Recent studies have shown that recapitulation of cell interactions with the extracellular matrix are key in tissue engineering, where the aim is to mimic and regenerate endogenous tissues. Because of this, incorporation of glycosaminoglycans to drive stem cell fate and promote cell proliferation in engineered tissues has gained increasing attention. This review summarizes the role glycosaminoglycans can play in tissue engineering and the recent advances in their use in these constructs. We also evaluate the general trend of research in this niche and provide insight into its future directions.
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