Omega-3 Fatty Acids Interact with DPP10 Region Genotype in Association with Childhood Atopy.
Omega-3 Fatty Acids Interact with DPP10 Region Genotype in Association with Childhood Atopy.
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DOI：
10.3390/nu15102416
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发表时间：
2023-05-22
期刊：
影响因子：
5.9
通讯作者：
Weiss ST
中科院分区：
文献类型：
--
作者：
Lee-Sarwar KA;Fischer-Rasmussen K;Bønnelykke K;Bisgaard H;Chawes B;Kelly RS;Lasky-Su J;Zeiger RS;O'Connor GT;Bacharier LB;Carey VJ;Laranjo N;Litonjua AA;Weiss ST
Omega-3脂肪酸(n-3)与过敏性疾病的关联是不一致的，可能部分是由于遗传变异。我们试图在维生素D产前哮喘减少试验(VDAART)和2010年哥本哈根儿童哮喘前瞻性研究(COPSAC)的参与者中识别和验证改变n-3与儿童哮喘或特应性疾病关联的基因变异。膳食n-3来自食物频率问卷，非靶向质谱仪测定儿童早期和6岁儿童的血浆n-3水平。从6个候选基因/基因区域和全基因组范围内寻找与6岁时哮喘或特应性疾病相关的n-3基因与基因的交互作用。DPP10区域的两个单核苷酸多态(rs958457和rs1516311)在VDAART组3岁时与血浆n-3相互作用(p=0.007和0.003)，在COPSAC组18个月龄时与血浆n-3相互作用(p=0.01和0.02)。另一个DPP10区域rs1367180在VDAART中与日粮n-3在6岁时相互作用(p=0.009)，在COPSAC中在6岁时与血浆n-3相互作用(p=0.004)。没有发现哮喘患者存在重复的相互作用。N-3在减少儿童过敏性疾病方面的作用可能因个体因素而异，包括DPP10区域的遗传变异。
Associations of omega-3 fatty acids (n-3) with allergic diseases are inconsistent, perhaps in part due to genetic variation. We sought to identify and validate genetic variants that modify associations of n-3 with childhood asthma or atopy in participants in the Vitamin D Antenatal Asthma Reduction Trial (VDAART) and the Copenhagen Prospective Studies on Asthma in Childhood 2010 (COPSAC). Dietary n-3 was derived from food frequency questionnaires and plasma n-3 was measured via untargeted mass spectrometry in early childhood and children aged 6 years old. Interactions of genotype with n-3 in association with asthma or atopy at age 6 years were sought for six candidate genes/gene regions and genome-wide. Two SNPs in the region of DPP10 (rs958457 and rs1516311) interacted with plasma n-3 at age 3 years in VDAART (p = 0.007 and 0.003, respectively) and with plasma n-3 at age 18 months in COPSAC (p = 0.01 and 0.02, respectively) in associationwith atopy. Another DPP10 region SNP, rs1367180, interacted with dietary n-3 at age 6 years in VDAART (p = 0.009) and with plasma n-3 at age 6 years in COPSAC (p = 0.004) in association with atopy. No replicated interactions were identified for asthma. The effect of n-3 on reducing childhood allergic disease may differ by individual factors, including genetic variation in the DPP10 region.
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影响因子：
5.4
作者：
de Oliveira Otto MC;Wu JH;Baylin A;Vaidya D;Rich SS;Tsai MY;Jacobs DR Jr;Mozaffarian D
通讯作者：
Mozaffarian D
DOI：
10.1158/1055-9965.epi-09-0869
发表时间：
2010-02
期刊：
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影响因子：
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通讯作者：
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影响因子：
3.7
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通讯作者：
LISA study group
DOI：
10.1164/rccm.201604-0861oc
发表时间：
2017-02-15
影响因子：
24.7
作者：
Almoguera, Berta;Vazquez, Lyam;Hakonarson, Hakon
通讯作者：
Hakonarson, Hakon
影响因子：
5.9
作者：
Barman, Malin;Nilsson, Staffan;Sandberg, Ann-Sofie
通讯作者：
Sandberg, Ann-Sofie