Variants of the FADS1 FADS2 gene cluster, blood levels of polyunsaturated fatty acids and eczema in children within the first 2 years of life.
Variants of the FADS1 FADS2 gene cluster, blood levels of polyunsaturated fatty acids and eczema in children within the first 2 years of life.
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DOI：
10.1371/journal.pone.0013261
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发表时间：
2010-10-11
期刊：
影响因子：
3.7
通讯作者：
LISA study group
中科院分区：
文献类型：
--
作者：
Rzehak P;Thijs C;Standl M;Mommers M;Glaser C;Jansen E;Klopp N;Koppelman GH;Singmann P;Postma DS;Sausenthaler S;Dagnelie PC;van den Brandt PA;Koletzko B;Heinrich J;KOALA study group;LISA study group
fads1 - fads2基因簇的遗传变异与成年人血液中脂肪酸组成的关系已经得到了很好的证实。我们在两个儿童队列研究中分析了这种遗传关联。此外，还研究了fads基因簇变异与血脂肪酸组成与湿疹之间的关系。将荷兰和德国两个人群出生队列（KOALA， LISA）的数据汇总（n = 879），并通过logistic回归分析fads基因群（rs174545, rs174546, rs174556, rs174561, rs3834458）中单核苷酸多态性（snp）对2岁前血液和父母报告的湿疹多不饱和脂肪酸（PUFA）的相互影响。除α -亚麻酸和二十碳五烯酸外，所有snp都与所有pufa高度显著相关，同样经过多次检验校正。在lisa研究中，所有测试的snp都显示与湿疹有关，但在koala研究中没有。无论是在汇总分析还是按研究队列分层分析中，均没有PUFAs与湿疹显著相关。幼儿血液中pufa的组成受fads基因簇的强烈控制。这些遗传变异与湿疹之间的联系发现了不一致的结果。血液中的多聚脂肪酸与湿疹无关。因此，通过lc -PUFA作为炎性前列腺素和白三烯的前体的代谢途径，PUFA与湿疹之间存在炎症联系的假设无法通过这些数据得到证实。
Association of genetic-variants in the FADS1-FADS2-gene-cluster with fatty-acid-composition in blood of adult-populations is well established. We analyze this genetic-association in two children-cohort-studies. In addition, the association between variants in the FADS-gene-cluster and blood-fatty-acid-composition with eczema was studied. Data of two population-based-birth-cohorts in the Netherlands and Germany (KOALA, LISA) were pooled (n = 879) and analyzed by (logistic) regression regarding the mutual influence of single-nucleotide-polymorphisms (SNPs) in the FADS-gene-cluster (rs174545, rs174546, rs174556, rs174561, rs3834458), on polyunsaturated fatty acids (PUFA) in blood and parent-reported eczema until the age of 2 years. All SNPs were highly significantly associated with all PUFAs except for alpha-linolenic-acid and eicosapentaenoic-acid, also after correction for multiple-testing. All tested SNPs showed associations with eczema in the LISA-study, but not in the KOALA-study. None of the PUFAs was significantly associated with eczema neither in the pooled nor in the analyses stratified by study-cohort. PUFA-composition in young children's blood is under strong control of the FADS-gene-cluster. Inconsistent results were found for a link between these genetic-variants with eczema. PUFA in blood was not associated with eczema. Thus the hypothesis of an inflammatory-link between PUFA and eczema by the metabolic-pathway of LC-PUFAs as precursors for inflammatory prostaglandins and leukotrienes could not be confirmed by these data.
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影响因子：
7.1
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