Functional interactions by transfer RNAs in the ribosome.

Functional interactions by transfer RNAs in the ribosome.
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DOI:
10.1016/j.febslet.2009.11.034
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发表时间:
2010-01-21
期刊:
影响因子:
3.5
通讯作者:
Joseph S
Joseph S
中科院分区:
生物学3区
文献类型:
--
作者:
Khade P;Joseph S

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最近的X射线晶体结构的核糖体已经彻底改变了该领域提供了一个急需的结构框架,以了解核糖体的功能。事实上,晶体结构使50多年来精心收集的许多遗传和生物化学数据合理化。在这里,我们专注于tRNA和核糖体之间的相互作用,并描述了一些结构提供的关于翻译机制的见解。高分辨率结构和功能研究对于充分理解蛋白质合成的复杂过程至关重要。
Recent X-ray crystal structures of the ribosome have revolutionized the field by providing a much-needed structural framework to understand ribosome function. Indeed, the crystal structures rationalize much of the genetic and biochemical data that have been meticulously gathered over 50 years. Here, we focus on the interactions between tRNAs and the ribosome and describe some of the insights that the structures provide about the mechanism of translation. Both high-resolution structures and functional studies are essential for fully appreciating the complex process of protein synthesis.
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