Serum C1q concentration is associated with disease activity in Chinese Takayasu arteritis patients: A case-control study.
Serum C1q concentration is associated with disease activity in Chinese Takayasu arteritis patients: A case-control study.
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DOI：
10.1002/hsr2.252
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发表时间：
2021-06
影响因子：
2
通讯作者：
Yuan H
中科院分区：
文献类型：
--
作者：
Chen S;Luan H;He J;Wang Y;Zeng X;Li Y;Yuan H
C1q 是经典补体途径的重要组成部分。本研究首次评估了中国大动脉炎 (TA) 患者疾病活动度与 C1q 血清水平之间的关联。评估198名TA患者和154名健康对照者的血清C1q水平，并分析血清C1q水平与TA疾病活动指数之间的关系。此外，我们还检查了血清 C1q 水平与两种传统炎症生物标志物之间的相关性；红细胞沉降率 (ESR) 和超敏 CRP (hs-CRP)。与健康对照相比，TA 患者的血清 C1q 水平升高 (P = .008)。患有活动性疾病的 TA 患者的血清 C1q 水平高于患有非活动性疾病的患者 (P < .0001)。此外，与接受过皮质类固醇或至少一种免疫抑制剂治疗的患者相比，初治患者的血清 C1q 水平较高 (P = .001)。此外，还发现 TA 患者血清 C1q 水平与传统炎症生物标志物呈正相关。研究了C1q在评估疾病活动中的作用，C1q预测活动性疾病的受试者工作特征曲线下面积（AUC）为0.752，167.15 mg/L C1q的血清截止值最大限度地发挥了疾病活动评估的能力，敏感性/特异性为77.80%/64.90%。当三个指标（C1q、ESR和hs-CRP）组合时，AUC增加到0.845，敏感性达到84.40%。血清C1q与TA的疾病活动度相关，C1q、ESR和hs-CRP三个指标的联合增加了疾病活动度评估的敏感性。
C1q is a crucial component of the classical complement pathway. This study is the first to assess the association between disease activity and serum levels of C1q in Chinese Takayasu arteritis (TA) patients. Serum C1q levels in 198 TA patients and 154 healthy controls were assessed, and the relationship between serum C1q levels and indices of TA disease activity was analyzed. Moreover, we examined the correlation between serum C1q levels and two traditional inflammatory biomarkers; erythrocyte sedimentation rate (ESR) and hypersensitive CRP (hs‐CRP). Serum C1q levels were increased in TA patients compared with healthy controls (P = .008). TA patients with active disease had higher levels of serum C1q than patients who had inactive disease (P < .0001). In addition, treatment‐naïve patients had higher serum C1q levels than those who had been treated with corticosteroids or at least one immunosuppressant (P = .001). Furthermore, a positive correlation between serum C1q levels and traditional inflammatory biomarkers in TA patients was found. The role of C1q in assessing disease activity was studied, and the area under the receiver operating characteristic curve (AUC) of C1q for predicting active disease was 0.752, and a serum cutoff value of 167.15 mg/L C1q maximized the ability of disease activity assessment, with a sensitivity/specificity of 77.80%/64.90%. When the three indicators (C1q, ESR, and hs‐CRP) were combined, the AUC increased to 0.845, and the sensitivity to 84.40%. The serum C1q is associated with the disease activity of TA and the combination of three indicators (C1q, ESR, and hs‐CRP) increases the sensitivity of disease activity assessment.
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