Islet inflammation in plain sight.
Islet inflammation in plain sight.
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DOI：
10.1111/dom.12160
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发表时间：
2013-09
期刊：
影响因子：
--
通讯作者：
Berggren PO
中科院分区：
文献类型：
--
作者：
Abdulreda MH;Berggren PO
虽然糖尿病正在达到大流行的程度，但1型（T1 D）或2型糖尿病（T2 D）的确切病因仍有待确定。然而，越来越多的证据表明，胰岛炎症可能是两种疾病早期发展的共同点。在这篇综述中，我们强调了T1 D和T2 D之间共享的一些炎症机制，并探讨了活体成像在胰岛炎症研究中的应用。活体成像已经成为生物医学研究中不可或缺的工具，并且已经开发了各种体内成像方法来研究健康和疾病中天然环境中的胰岛生理学和病理生理学。然而，考虑到胰岛在位于体内深处的外分泌胰腺的“海”内的分散分布以及胰岛仅构成胰腺组织总体积的1 - 2%的事实，原位研究胰岛具有挑战性。在这里，我们专注于一种新的实验方法，使研究局部胰岛炎症与单细胞分辨率在相关的背景下，在体内环境的非侵入性和纵向，从而提高我们对糖尿病发病机制的理解。
Although, diabetes is reaching pandemic proportions, the exact etiology of either type 1 (T1D) or type 2 diabetes (T2D) remains to be determined. Mounting evidence, however, suggests that islet inflammation is a likely common denominator during early development of either type of the disease. In this review, we highlight some of the inflammatory mechanisms that appear to be shared between T1D and T2D, and we explore the utility of intravital imaging in the study of islet inflammation. Intravital imaging has emerged as an indispensable tool in biomedical research and a variety of in vivo imaging approaches have been developed to study pancreatic islet physiology and pathophysiology in the native environment in health and disease. However, given the scattered distribution of the islets of Langerhans within the “sea” of the exocrine pancreas located deep within the body and the fact that the islets only constitute 1 – 2% of the total volume of pancreatic tissue, studying the pancreatic islet in situ has been challenging. Here, we focus on a new experimental approach that enables studying local islet inflammation with single cell-resolution in the relevant context of the in vivo environment non-invasively and longitudinally and, thereby improving our understanding of diabetes pathogenesis.
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影响因子：
1.2
作者：
Abdulreda, Midhat H.;Caicedo, Alejandro;Berggren, Per-Olof
通讯作者：
Berggren, Per-Olof
DOI：
10.1073/pnas.1105002108
发表时间：
2011-08-02
影响因子：
11.1
作者：
Abdulreda, Midhat H.;Faleo, Gaetano;Berggren, Per-Olof
通讯作者：
Berggren, Per-Olof
影响因子：
64.8
作者：
FALCK, B
通讯作者：
FALCK, B
影响因子：
2.9
作者：
ADEGHATE, E;DONATH, T
通讯作者：
DONATH, T
影响因子：
2.8
作者：
Choi, Hyung Jin;Hwang, Seungwoo;Cho, Young Min
通讯作者：
Cho, Young Min