Associations of childhood experiences with event-related potentials in adults with autism spectrum disorder
Associations of childhood experiences with event-related potentials in adults with autism spectrum disorder
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患有自闭症谱系障碍的成年人的童年经历与事件相关电位的关联
DOI：
10.1038/s41598-020-70409-z
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发表时间：
2020
影响因子：
4.6
通讯作者：
Kishimoto Toshifumi
中科院分区：
文献类型：
--
作者：
Okazaki Kosuke;Ota Toyosaku;Makinodan Manabu;Kishimoto Naoko;Yamamuro Kazuhiko;Ishida Rio;Takahashi Masato;Yasuda Yuka;Hashimoto Ryota;Iida Junzo;Kishimoto Toshifumi
儿童期虐待被定义为在儿童期遭受身体、情感和性虐待以及忽视。儿童时期的虐待会导致一般人在以后的生活中出现严重的心理社会问题。自闭症谱系障碍（ASD）患者在童年时期经历压力和创伤事件（如虐待）的风险更高。虽然据报道，儿童期虐待会导致ASD成年人的心理社会问题，但这一人群中儿童期经历与大脑功能之间的生物学联系仍未得到充分研究。在这里，我们评估了儿童的经验和事件相关电位（ERP）组件之间的关系，在听觉奇球任务的成人ASD（N = 21）和典型发达（TD）的个人（N = 22）。我们发现，ASD患者性虐待的严重程度越高，Fz，Cz，C3和C4的P300振幅越大。相反，儿童虐待的严重程度与TD个体Cz和C3的P300潜伏期相关。此外，在TD个体中，全智商与Fz、Cz、C3和C4处的MMN振幅显著相关。这些研究结果提供了第一个证据，ERPs可用于研究童年经历对ASD患者大脑的影响，并且儿童期性虐待对这一人群的大脑功能有显着影响。
Childhood maltreatment is defined as experiencing of physical, emotional and sexual abuse and neglect in childhood. Maltreatment in childhood leads to substantial psychosocial problems later in life in the general population. Individuals with autism spectrum disorder (ASD) have a higher risk of experiencing stressful and traumatic events, such as maltreatment, during childhood. Although childhood maltreatment reportedly leads to psychosocial problems in adults with ASD, the biological associations between childhood experiences and brain function in this population remain understudied. Here, we evaluated the relationships between childhood experiences and event-related potential (ERP) components during the auditory odd-ball task in adults with ASD (N = 21) and typically developed (TD) individuals (N = 22). We found that the higher the severity of sexual abuse, the larger the amplitude of P300 at Fz, Cz, C3, and C4 in individuals with ASD. Conversely, the severity of child maltreatment was associated with P300 latency at Cz and C3 in TD individuals. Moreover, full IQ was significantly associated with the MMN amplitude at Fz, Cz, C3, and C4 in TD individuals. These findings provide the first evidence that ERPs could be used to study the impacts childhood experiences on the brain of individuals with ASD and that childhood sexual abuse has salient impacts on brain function in this population.
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人类的视觉诱发潜力
DOI：
--
发表时间：
2010
期刊：
影响因子：
--
作者：
S. Hillyard
通讯作者：
S. Hillyard
影响因子：
3.7
作者：
Cygan HB;Tacikowski P;Ostaszewski P;Chojnicka I;Nowicka A
通讯作者：
Nowicka A
影响因子：
26.1
作者：
Jensen, Sarah K. G.;Dickie, Erin W.;Schwartz, Deborah H.;Evans, C. John;Dumontheil, Iroise;Paus, Tomas;Barker, Edward D.
通讯作者：
Barker, Edward D.
精神分裂症患者阅读句子时内容词和功能词引发的事件相关电位
影响因子：
11.9
作者：
A. Takashima;K. Ohta;E. Matsushima;M. Toru
通讯作者：
M. Toru
影响因子：
--
作者：
Green, Jennifer Greif;McLaughlin, Katie A.;Berglund, Patricia A.;Gruber, Michael J.;Sampson, Nancy A.;Zaslavsky, Alan M.;Kessler, Ronald C.
通讯作者：
Kessler, Ronald C.