The role of microglia in adult hippocampal neurogenesis.

The role of microglia in adult hippocampal neurogenesis.
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DOI:
10.3389/fncel.2013.00229
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发表时间:
2013-11-22
影响因子:
5.3
通讯作者:
Bachstetter AD
Bachstetter AD
中科院分区:
医学2区
文献类型:
--
作者:
Gemma C;Bachstetter AD

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在过去的十年里,我们对小胶质细胞的看法发生了巨大的变化。从健康大脑中“沉默”的细胞开始,小胶质细胞已经积极参与几种大脑生理功能,包括成年海马神经发生以及认知和行为功能。鉴于最近的发现揭示了小胶质细胞作为神经元回路重组的重要效应器的作用,相当多的注意力集中在小胶质细胞和海马神经发生如何可能是一个相互依赖的现象。本文就生理条件下小胶质细胞在成年海马神经发生中的作用作一综述。
Our view of microglia has dramatically changed in the last decade. From cells being “silent” in the healthy brain, microglia have emerged to be actively involved in several brain physiological functions including adult hippocampal neurogenesis, and cognitive and behavioral function. In light of recent discoveries revealing a role of microglia as important effectors of neuronal circuit reorganization, considerable attention has been focused on how microglia and hippocampal neurogenesis could be an interdependent phenomenon. In this review the role of microglia in the adult hippocampal neurogenesis under physiological condition is discussed.
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