Aspirin and omega-3 fatty acid status interact in the prevention of cardiovascular diseases in Framingham Heart Study.
Aspirin and omega-3 fatty acid status interact in the prevention of cardiovascular diseases in Framingham Heart Study.
复制标题
DOI：
10.1016/j.plefa.2021.102283
复制
发表时间：
2021-06
期刊：
影响因子：
--
通讯作者：
Tintle N
中科院分区：
文献类型：
--
作者：
Block RC;Shearer GC;Holub A;Tu XM;Mousa S;Brenna JT;Harris WS;Tintle N
omega-3（n3）脂肪酸[二十碳五烯酸（EPA）和二十二碳六烯酸（DHA）]和低剂量阿司匹林在缺血性心血管疾病（CVD）一级预防中的作用存在争议。由于omega-3（n3）脂肪酸和阿司匹林影响血小板中的环氧合酶活性，因此阿司匹林与每个个体中存在的特定n3脂肪酸水平结合可能具有临床相关作用。在心脏病研究中，对2500名没有已知CVD的参与者进行了RBC EPA + DHA、花生四烯酸（AA）和二十二碳五烯酸（DPA）的测量。然后，我们测试了与报告的阿司匹林使用（1004报告使用和1494没有）对CVD结果的相互作用。中位随访时间为7.2年。RBC EPA + DHA在第二个五分位数（占总脂肪酸的4.2 - 4.9%）与未来CVD事件的风险显著降低相关（相对于第一个五分位数，<4.2%）在那些没有服用阿司匹林的人中（HR 0.54（0.30，0.98）），但在报告使用阿司匹林的人群中，这五分之一人群的风险显著增加（HR 2.16（1.19，3.92））。当调整混杂因素时，这种相互作用仍然显著。使用相同的五分位数，冠心病和卒中结局也存在显著的相互作用。EPA和DHA单独存在类似的发现，但DPA和AA不存在。阿司匹林的使用和RBC EPA + DHA水平对CVD结果之间存在复杂的相互作用。这表明阿司匹林的使用可能在一种omega-3环境中有益，但在另一种环境中有害，这意味着可能需要个性化的方法来使用阿司匹林和omega-3补充剂。
The roles of omega-3 (n3) fatty acids [eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)] and low-dose aspirin in the primary prevention of ischemic cardiovascular disease (CVD) are controversial. Since omega-3 (n3) fatty acids and aspirin affect cyclooxygenase activity in platelets, there could be a clinically-relevant effect of aspirin combined with a particular n3 fatty acid level present in each individual. RBC EPA+DHA, arachidonic acid (AA) and docosapentaenoic acid (DPA) were measured in 2500 participants without known CVD in the Framingham Heart Study. We then tested for interactions with reported aspirin use (1004 reported use and 1494 did not) on CVD outcomes. The median follow-up was 7.2 years. Having RBC EPA+DHA in the second quintile (4.2–4.9% of total fatty acids) was associated with significantly reduced risk for future CVD events (relative to the first quintile, <4.2%) in those who did not take aspirin (HR 0.54 (0.30, 0.98)), but in those reporting aspirin use, risk was significantly increased (HR 2.16 (1.19, 3.92)) in this quintile. This interaction remained significant when adjusting for confounders. Significant interactions were also present for coronary heart disease and stroke outcomes using the same quintiles. Similar findings were present for EPA and DHA alone but not for DPA and AA. There is a complex interaction between aspirin use and RBC EPA+DHA levels on CVD outcomes. This suggests that aspirin use may be beneficial in one omega-3 environment but harmful in another, implying that a personalized approach to both aspirin use and omega-3 supplementation may be needed.
登录
查看更多内容
影响因子：
37.8
作者：
Eikelboom, JW;Hirsh, J;Yusuf, S
通讯作者：
Yusuf, S
DOI：
10.1016/j.plefa.2012.12.004
发表时间：
2013-04-01
影响因子：
3
作者：
Harris, William S.;Pottala, James V.;McConnell, Joseph P.
通讯作者：
McConnell, Joseph P.
影响因子：
105.7
作者：
Krasopoulos, George;Brister, Stephanie J.;Buchanan, Michael R.
通讯作者：
Buchanan, Michael R.
影响因子：
5.1
作者：
Harris, WS;von Schacky, C
通讯作者：
von Schacky, C
影响因子：
7.5
作者：
HARRIS, WS;SILVEIRA, S;DUJOVNE, CA
通讯作者：
DUJOVNE, CA