Thalamic GABA predicts fine motor performance in manganese-exposed smelter workers.
Thalamic GABA predicts fine motor performance in manganese-exposed smelter workers.
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DOI：
10.1371/journal.pone.0088220
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Dydak U
中科院分区：
文献类型：
--
作者：
Long Z;Li XR;Xu J;Edden RA;Qin WP;Long LL;Murdoch JB;Zheng W;Jiang YM;Dydak U
锰（Mn）过量可导致帕金森症状，包括运动缺陷。已知主要的抑制性神经递质γ-氨基丁酸（GABA）在运动的调节和表现中起关键作用。因此，本研究的目的是在测试的假设，改变GABA锰暴露后可能与精细运动表现在职业暴露的工人，可能是锰引起的运动缺陷的机制。一个队列的9锰暴露的男性冶炼厂工人从锰铁合金厂和23个性别和年龄匹配的对照组被招募，并进行神经系统检查，磁共振波谱（MRS）测量，和普渡钉板运动测试。采用短回波时间MRS检测N-乙酰天冬氨酸（NAA）和肌醇（mI）。用MEGA-PRESS J编辑MRS序列检测GABA。与对照组相比，冶炼厂工人的平均丘脑GABA水平显着增加（p = 0.009）。 多元线性回归分析显示：（1）GABA水平的增加与暴露持续时间之间存在显著相关性（R2 = 0.660，p = 0.039），（2）冶炼厂工人GABA水平与所有普渡钉板测试评分之间存在显著负相关性（所有评分总和R2 = 0.902，p = 0.001）。 此外，与对照组相比，冶炼厂工人的丘脑和PCC中的MI水平显著降低（分别为p= 0.030和p =0.009）。 总之，我们的研究结果表明丘脑GABA水平和精细运动性能之间存在明显的关联。因此，在锰暴露的主题，增加丘脑GABA水平可能作为一个生物标志物的微妙缺陷，在运动控制，并可能成为有价值的锰中毒的早期诊断。
Overexposure to manganese (Mn) may lead to parkinsonian symptoms including motor deficits. The main inhibitory neurotransmitter gamma-aminobutyric acid (GABA) is known to play a pivotal role in the regulation and performance of movement. Therefore this study was aimed at testing the hypothesis that an alteration of GABA following Mn exposure may be associated with fine motor performance in occupationally exposed workers and may underlie the mechanism of Mn-induced motor deficits. A cohort of nine Mn-exposed male smelter workers from an Mn-iron alloy factory and 23 gender- and age-matched controls were recruited and underwent neurological exams, magnetic resonance spectroscopy (MRS) measurements, and Purdue pegboard motor testing. Short-echo-time MRS was used to measure N-Acetyl-aspartate (NAA) and myo-inositol (mI). GABA was detected with a MEGA-PRESS J-editing MRS sequence. The mean thalamic GABA level was significantly increased in smelter workers compared to controls (p = 0.009). Multiple linear regression analysis reveals (1) a significant association between the increase in GABA level and the duration of exposure (R2 = 0.660, p = 0.039), and (2) significant inverse associations between GABA levels and all Purdue pegboard test scores (for summation of all scores R2 = 0.902, p = 0.001) in the smelter workers. In addition, levels of mI were reduced significantly in the thalamus and PCC of smelter workers compared to controls (p = 0.030 and p = 0.009, respectively). In conclusion, our results show clear associations between thalamic GABA levels and fine motor performance. Thus in Mn-exposed subjects, increased thalamic GABA levels may serve as a biomarker for subtle deficits in motor control and may become valuable for early diagnosis of Mn poisoning.
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