Anomalous gray matter structural networks in major depressive disorder.
Anomalous gray matter structural networks in major depressive disorder.
复制标题
主要抑郁症中的异常灰质结构网络。
DOI：
10.1016/j.biopsych.2013.03.005
复制
发表时间：
2013-11-15
影响因子：
10.6
通讯作者：
Gotlib, Ian H.
中科院分区：
文献类型：
--
作者：
Singh, Manpreet K.;Kesler, Shelli R.;Hosseini, S. M. Hadi;Kelley, Ryan G.;Amatya, Debha;Hamilton, J. Paul;Chen, Michael C.;Gotlib, Ian H.
重度抑郁症（MDD）的特征是在结构，功能和连接在几个大脑区域的异常。很少有研究探讨这些区域在大脑中是如何组织的，或者研究可能与抑郁症相关的网络水平结构畸变。我们使用图形分析来检查诊断为MDD的个体（n = 93）和一个人口统计学上相似的健康对照组（n = 151），没有精神病理学史的灰质结构网络。结构网络处理信息的效率是通过量化局部互连（聚类）和全局整合（路径长度）来确定的。我们还比较了高度数节点（即，枢纽）和区域网络措施，包括度（节点中的连接数）和介数（节点中的短路径连接比例）。抑郁的参与者在一系列网络密度中显着减少了大脑网络中的聚类。与对照组相比，抑郁症受试者较少的枢纽，主要是在内侧额和内侧颞区，有较高的程度，在左侧缘上回和右侧直回，并有较高的中间在右侧杏仁核和左侧内侧眶额回。与对照组相比，抑郁症患者的网络组织效率较低，区域连通性降低。杏仁核和内侧前额叶皮层的区域连接可能在维持或适应抑郁病理中发挥作用。这是第一个报告异常的大规模灰质结构网络在MDD和提供新的见解有关的神经生物学机制与这种疾病。
Major depressive disorder (MDD) is characterized by abnormalities in structure, function, and connectivity in several brain regions. Few studies have examined how these regions are organized in the brain or investigated network-level structural aberrations that might be associated with depression. We used graph analysis to examine the gray matter structural networks of individuals diagnosed with MDD (n = 93) and a demographically similar healthy comparison group (n = 151) with no history of psychopathology. The efficiency of structural networks for processing information was determined by quantifying local interconnectivity (clustering) and global integration (path length). We also compared the groups on the contributions of high-degree nodes (i.e., hubs) and regional network measures, including degree (number of connections in a node) and betweenness (fraction of short path connections in a node). Depressed participants had significantly decreased clustering in their brain networks across a range of network densities. Compared with control subjects, depressed participants had fewer hubs primarily in medial frontal and medial temporal areas, had higher degree in the left supramarginal gyrus and right gyrus rectus, and had higher betweenness in the right amygdala and left medial orbitofrontal gyrus. Networks of depressed individuals are characterized by a less efficient organization involving decreased regional connectivity compared with control subjects. Regional connections in the amygdala and medial prefrontal cortex may play a role in maintaining or adapting to depressive pathology. This is the first report of anomalous large-scale gray matter structural networks in MDD and provides new insights concerning the neurobiological mechanisms associated with this disorder.
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DOI：
10.1523/jneurosci.1929-08.2008
发表时间：
2008-09-10
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Bassett DS;Bullmore E;Verchinski BA;Mattay VS;Weinberger DR;Meyer-Lindenberg A
通讯作者：
Meyer-Lindenberg A
影响因子：
3.7
作者：
Blood AJ;Iosifescu DV;Makris N;Perlis RH;Kennedy DN;Dougherty DD;Kim BW;Lee MJ;Wu S;Lee S;Calhoun J;Hodge SM;Fava M;Rosen BR;Smoller JW;Gasic GP;Breiter HC;Phenotype Genotype Project on Addiction and Mood Disorders
通讯作者：
Phenotype Genotype Project on Addiction and Mood Disorders
影响因子：
5.7
作者：
Bassett, Danielle S.;Nelson, Brent G.;Mueller, Bryon A.;Camchong, Jazmin;Lim, Kelvin O.
通讯作者：
Lim, Kelvin O.
影响因子：
10.6
作者：
Frodl, Thomas;Bokde, Arun L. W.;Meisenzahl, Eva
通讯作者：
Meisenzahl, Eva
影响因子：
3.7
作者：
Chen, Zhang J.;He, Yong;Evans, Alan C.
通讯作者：
Evans, Alan C.