Increased postnatal concentrations of pro-inflammatory cytokines are associated with reduced IGF-I levels and retinopathy of prematurity.
Increased postnatal concentrations of pro-inflammatory cytokines are associated with reduced IGF-I levels and retinopathy of prematurity.
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DOI：
10.1016/j.ghir.2017.11.006
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发表时间：
2018-04
期刊：
影响因子：
--
通讯作者：
Hellström A
中科院分区：
文献类型：
--
作者：
Hellgren G;Löfqvist C;Hansen-Pupp I;Gram M;Smith LE;Ley D;Hellström A
早产儿视网膜病变 (ROP) 是一种多因素疾病，与低胰岛素样生长因子 (IGF)-I 水平以及可能与产后炎症有关。在这里，我们研究了促炎细胞因子白细胞介素 (IL)-6 和肿瘤坏死因子 (TNF)-α 的纵向产后血清浓度与 IGF-I 水平和 ROP 的关系。研究队列包括 52 名 31 孕周前出生的婴儿。对婴儿进行 ROP 筛查，并将其分为非 ROP（n = 33）、非增殖性 ROP（1 期和 2 期；n = 10）或增殖性 ROP（3 期，全部接受 ROP 治疗；n = 9）。出生时、出生后 24 小时采集血样，然后每周采集一次血样，直至月经后年龄 (PMA) 至少 36 周（即出生后最多 13 周）。评估IL-6和TNF-α的循环水平与循环IGF-I水平和ROP的关系。出生后 5 周至 8 周期间，IL-6 水平与 IGF-I 水平呈负相关（p < 0.01 至 p < 0.05）。出生时，IL-6 和 TNF-α 水平相似，与后来的 ROP 无关。出生后 24 小时，接受 ROP 治疗的婴儿的 IL-6 和 TNF-α 水平均升高（p < 0.05）。出生后，接受 ROP 治疗的婴儿比未接受 ROP 的婴儿具有更高的 IL-6 水平。促炎反应与低 IGF-I 水平和 ROP 的发生有关。
Retinopathy of prematurity (ROP) is a multifactorial disease linked to low insulin-like growth factor (IGF)-I levels and perhaps to postnatal inflammation. Here, we investigated the longitudinal postnatal serum concentrations of pro-inflammatory cytokines interleukin (IL)-6 and tumor necrosis factor (TNF)-α in relation to IGF-I levels and ROP. The study cohort included 52 infants born before 31 gestational weeks. The infants were screened for ROP and classified as non-ROP (n = 33), non-proliferative ROP (stages 1 and 2; n = 10), or proliferative ROP (stage 3, all treated for ROP; n = 9). Blood samples were collected at birth, 24 h after birth, and then weekly until at least 36 weeks postmenstrual age (PMA) (i.e., up to 13 weeks after birth). Circulating levels of IL-6 and TNF-α were evaluated in relation to circulating IGF-I levels and ROP. IL-6 levels negatively correlated with IGF-I levels between 5 and 8 weeks after birth, (p < 0.01 to p < 0.05). At birth, the IL-6 and TNF-α levels were similar independent of later ROP. Twenty-four hours after birth, both IL-6 and TNF-α levels had increased in infants later treated for ROP (p < 0.05). Postnatal, infants treated for ROP had higher IL-6 levels than infants without ROP. The pro-inflammatory response is associated with low IGF-I levels and the development of ROP.
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DOI：
10.1097/iae.0000000000001247
发表时间：
2017-05
期刊：
Retina (Philadelphia, Pa.)
影响因子：
--
作者：
Jensen AK;Ying GS;Huang J;Quinn GE;Binenbaum G
通讯作者：
Binenbaum G
DOI：
10.1097/00075197-200205000-00006
发表时间：
2002-05-01
影响因子：
3.1
作者：
Lang, CH;Frost, RA
通讯作者：
Frost, RA
影响因子：
5.1
作者：
Di Fiore, Juliann M.;Bloom, Jeffrey N.;Martin, Richard J.
通讯作者：
Martin, Richard J.
影响因子：
9.8
作者：
Chen, Jing;Smith, Lois E. H.
通讯作者：
Smith, Lois E. H.
影响因子：
6
作者：
Gardiner, TA;Gibson, DS;Stitt, AW
通讯作者：
Stitt, AW