Recent advances in LDH-based nanosystems for cancer therapy
Recent advances in LDH-based nanosystems for cancer therapy
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基于 LDH 的癌症治疗纳米系统的最新进展
DOI：
10.1016/j.matdes.2020.109298
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发表时间：
2021-01
影响因子：
8.4
通讯作者：
Shiguo Sun
中科院分区：
文献类型：
--
作者：
Jia Wen;Kui Yang;Jie Huang;Shiguo Sun
癌症已成为世界上最大的死亡原因之一。癌症的治疗仍然是一个大问题。随着纳米技术的发展，层状双氢氧化物（LDH）纳米体系因其良好的生物相容性、pH依赖性、阴离子交换能力、表面修饰容易、化学稳定性高等优点而备受关注，在肿瘤治疗中具有巨大的应用潜力。在过去的十年中，基于LDH的纳米系统已被构建用于各种癌症治疗。然而，很少有评论文章描述了这些重要的和有前途的成就，以促进LDH及其纳米复合材料的进一步发展。本文综述了LDH及其纳米复合物作为强大的纳米系统用于多种癌症治疗的最新进展，分为化疗、光疗、基因治疗、免疫治疗和联合治疗五个部分。本文还概述了LDH及其纳米复合材料用于癌症治疗的未来前景和当前面临的挑战。
Cancer has become one of the greatest causes of death around the world. The treatment of cancer still remains a great problem. With recent advances made in the field of nanotechnology, layered double hydroxide (LDH)-based nanosystems have drawn special attention because of their good biocompatibility, pH-dependent biodegradability, anion exchange capacity, easy surface modification and high chemical stability, giving rise to great potential for cancer therapy. In the past decade, LDH-based nanosystems have been constructed for various cancer therapies. However, few review articles have described these important and promising achievements to promote the further development of LDH and its nanocomposites. This review aims to provide a comprehensive overview on the recent developments in LDH and its nanocomposites as powerful nanosystems for diverse cancer therapies, which is divided into five parts: chemotherapy, phototherapy, gene therapy, immunotherapy and combination therapy. This review also outlines future perspectives and current challenges in LDH and its nanocomposites for cancer therapy.
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影响因子：
5
作者：
N’guadi Blaise Allou;J. Saikia;Polakshi Bordoloi;A. Yadav;Mintu Pal;R. L. Goswamee
通讯作者：
N’guadi Blaise Allou;J. Saikia;Polakshi Bordoloi;A. Yadav;Mintu Pal;R. L. Goswamee
影响因子：
6.7
作者：
Zhaojie Wang;Peng Liang;Xiaolie He;Bin Wu;Qiang Liu;Ziping Xu;Huijun Wu;Zhongmin Liu;Yechang Qian;Shilong Wang;Rongrong Zhu
通讯作者：
Zhaojie Wang;Peng Liang;Xiaolie He;Bin Wu;Qiang Liu;Ziping Xu;Huijun Wu;Zhongmin Liu;Yechang Qian;Shilong Wang;Rongrong Zhu
影响因子：
5.9
作者：
Cecilia Martini;C. Ferroni;M. Gariboldi;A. Donnadio;A. Aluigi;G. Sotgiu;F. Liscio;P. Dambruoso;Maria Luisa Navacchia;Tamara Posati;G. Varchi
通讯作者：
Cecilia Martini;C. Ferroni;M. Gariboldi;A. Donnadio;A. Aluigi;G. Sotgiu;F. Liscio;P. Dambruoso;Maria Luisa Navacchia;Tamara Posati;G. Varchi
影响因子：
5.6
作者：
M. Lobo-Sánchez;Gisel Nájera-Meléndez;G. Luna;Verónica Segura-Pérez;J. A. Rivera;G. Fetter
通讯作者：
M. Lobo-Sánchez;Gisel Nájera-Meléndez;G. Luna;Verónica Segura-Pérez;J. A. Rivera;G. Fetter
氧化石墨烯-药物插层层状双氢氧化物杂化薄膜的控释特性及增强抗菌作用
影响因子：
--
作者：
Wang, Yi;Zhang, Dun;Wan, Yi
通讯作者：
Wan, Yi