Role of autophagy in metabolic syndrome-associated heart disease.
Role of autophagy in metabolic syndrome-associated heart disease.
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DOI：
10.1016/j.bbadis.2014.04.029
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发表时间：
2015-02
影响因子：
6.2
通讯作者：
Xu, Xihui
中科院分区：
文献类型：
--
作者：
Ren, Sidney Y.;Xu, Xihui
代谢综合征（MetS）是多种代谢危险因素的集合，包括腹部肥胖、葡萄糖耐受不良、胰岛素抵抗、血脂异常和高血压。在过去的几十年里，代谢综合征的发病率急剧上升，对健康构成了毁灭性的大流行威胁。更重要的是，患有代谢综合征的人患糖尿病和心血管疾病的风险更高。代谢综合征的常见合并症之一是心脏异常，导致心肌细胞丧失，心功能障碍，最终心力衰竭。尽管肥胖相关的心脏功能障碍的确切作用机制尚不清楚，但肥胖心脏并发症的发病机制包括脂肪毒性、炎症、氧化应激、细胞凋亡和交感神经过度激活等多种细胞信号通路。最近的证据表明，蛋白质质量控制在代谢综合征组成部分的潜在作用。在蛋白质质量控制系统中，自噬-溶酶体途径是一个进化上保守的途径，负责细胞内大型细胞器和蛋白质聚集体的大量降解。自噬已被证明在生理和病理条件下维持心脏的几何形状和功能中起着不可或缺的作用。越来越多的研究表明，自噬在肥胖和代谢综合征下心脏异常的病因学中起着关键作用。在这篇综述中，我们将讨论自噬如何参与肥胖和代谢综合征心功能的调节。
Metabolic syndrome (MetS) is a constellation of multiple metabolic risk factors including abdominal obesity, glucose intolerance, insulin resistance, dyslipidemia and hypertension. Over the past decades, the prevalence of metabolic syndrome has increased dramatically, imposing a devastating, pandemic health threat. More importantly, individuals with metabolic syndrome are at an increased risk of diabetes mellitus and overall cardiovascular diseases. One of the common comorbidities of metabolic syndrome is heart anomalies leading to the loss of cardiomyocytes, cardiac dysfunction and ultimately heart failure. Up-to-date, a plethora cell signaling pathways have been postulated for the pathogenesis of cardiac complications in obesity including lipotoxicity, inflammation, oxidative stress, apoptosis and sympathetic overactivation although the precise mechanism of action underscoring obesity-associated heart dysfunction remains elusive. Recent evidence has indicated a potential role of protein quality control in components of metabolic syndrome. Within the protein quality control system, the autophagy-lysosome pathway is an evolutionarily conserved pathway responsible for bulk degradation of large intracellular organelles and protein aggregates. Autophagy has been demonstrated to play an indispensible role in the maintenance of cardiac geometry and function under both physiological and pathological conditions. Accumulating studies have demonstrated that autophagy plays a pivotal role in the etiology of cardiac anomalies under obesity and metabolic syndrome. In this mini review, we will discuss on how autophagy is involved in the regulation of cardiac function in obesity and metabolic syndrome.
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