Dopamine depletion in either the dorsomedial or dorsolateral striatum impairs egocentric Cincinnati water maze performance while sparing allocentric Morris water maze learning.
Dopamine depletion in either the dorsomedial or dorsolateral striatum impairs egocentric Cincinnati water maze performance while sparing allocentric Morris water maze learning.
复制标题
DOI：
10.1016/j.nlm.2014.10.009
复制
发表时间：
2015-02
影响因子：
2.7
通讯作者：
Williams, Michael T.
中科院分区：
文献类型：
--
作者：
Braun, Amanda A.;Amos-Kroohs, Robyn M.;Gutierrez, Arnold;Lundgren, Kerstin H.;Seroogy, Kim B.;Skelton, Matthew R.;Vorhees, Charles V.;Williams, Michael T.
分别通过辛辛那提水迷宫（CWM）和Morris水迷宫（MWM）评估的基于自我中心的路径学习和空间学习在6-羟基多巴胺（6-OHDA）给药后大鼠新纹状体中多巴胺（DA）损失80%后受损。背外侧纹状体（DLS）和背内侧纹状体（DMS）参与不同的导航学习类型，即DLS参与自我中心学习，而DMS参与空间学习。该实验测试了通过DMS或DLS中的6-OHDA病变的选择性DA损失是否会损害一种或两种类型的导航。DLS和DMS DA损失显着损害基于路线的CWM学习，而不影响空间或线索MWM性能。DLS 6-OHDA病变在该区域产生75%的DA损失，DLS或DMS中的其他单胺水平没有变化。DMS 6-OHDA损伤在该区域产生62%的DA损失，而不影响DMS或DLS中的其他单胺水平。结果表明，DA在DLS和DMS区域的作用，以路线为基础的自我中心，但不是空间学习和记忆。空间学习缺陷可能需要更普遍的单胺减少在每个区域内的赤字表现出来之前。这是第一个研究牵连DLS和DMS DA在基于路线的自我中心导航。
Both egocentric route-based learning and spatial learning, as assessed by the Cincinnati water maze (CWM) and Morris water maze (MWM), respectively, are impaired following an 80% dopamine (DA) loss in the neostriatum after 6-hydroxydopamine (6-OHDA) administration in rats. The dorsolateral striatum (DLS) and the dorsomedial striatum (DMS) are implicated in different navigational learning types, namely the DLS is implicated in egocentric learning while the DMS is implicated in spatial learning. This experiment tested whether selective DA loss through 6-OHDA lesions in the DMS or DLS would impair one or both types of navigation. Both DLS and DMS DA loss significantly impaired route-based CWM learning, without affecting spatial or cued MWM performance. DLS 6-OHDA lesions produced a 75% DA loss in this region, with no changes in other monoamine levels in the DLS or DMS. DMS 6-OHDA lesions produced a 62% DA loss in this region, without affecting other monoamine levels in the DMS or DLS. The results indicate a role for DA in DLS and DMS regions in route-based egocentric but not spatial learning and memory. Spatial learning deficits may require more pervasive monoamine reductions within each region before deficits are exhibited. This is the first study to implicate DLS and DMS DA in route-based egocentric navigation.
登录
查看更多内容
影响因子：
5.3
作者：
Kim, Hoseok;Lee, Daeyeol;Jung, Min Whan
通讯作者：
Jung, Min Whan
影响因子：
2.9
作者：
LAVOIE, AM;MIZUMORI, SJY
通讯作者：
MIZUMORI, SJY
影响因子：
3.7
作者：
Calaminus, Carsten;Hauber, Wolfgang
通讯作者：
Hauber, Wolfgang
DOI：
10.1016/s0163-1047(88)90338-x
发表时间：
1988-05-01
期刊：
BEHAVIORAL AND NEURAL BIOLOGY
影响因子：
--
作者：
COOK, D;KESNER, RP
通讯作者：
KESNER, RP
影响因子：
2.9
作者：
Aquiar, Lissiana My.;Macedo, Danielle S.;Viana, Glauce S. B.
通讯作者：
Viana, Glauce S. B.