Immunogenicity of Haemophilus influenzae type b polysaccharide-outer membrane protein conjugate vaccine in patients who acquired Haemophilus disease despite previous vaccination with type b polysaccharide vaccine.
Immunogenicity of Haemophilus influenzae type b polysaccharide-outer membrane protein conjugate vaccine in patients who acquired Haemophilus disease despite previous vaccination with type b polysaccharide vaccine.
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b 型流感嗜血杆菌多糖-外膜蛋白结合疫苗对尽管先前接种过 b 型多糖疫苗但仍感染嗜血杆菌病的患者的免疫原性。
DOI：
10.1016/s0022-3476(89)80432-9
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Sheetz,KE
中科院分区：
文献类型：
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作者：
Granoff,DM;Chacko,A;Lottenbach,KR;Sheetz,KE
为探讨既往接种过B型流感嗜血杆菌（HiB）多糖疫苗后仍发生侵袭性嗜血杆菌病的儿童免疫缺陷的基础，我们测定了血清抗囊抗体水平低（<1 μg/ml）的疫苗失败患者对再免疫应答的能力。34例患者，年龄从27个月到61个月不等，接种Hib多糖（n=20）或Hib多糖-外膜蛋白结合物疫苗（n=14）。除3名儿童外，所有儿童的血清免疫球蛋白浓度均正常，包括IgG 2。免疫后1个月，多糖疫苗组的血清抗囊抗体浓度几何平均值由免疫前的0.27 μg/ml上升到0.65 μg/ml（P<0.05），但应答幅度比31名年龄匹配的对照组（6.3 μg/ml，P<0.001）低近10倍。相反，所有14名接种结合疫苗失败的患者的血清抗囊抗体均增加了5倍或更多（几何平均值分别为0.35和12.8 μg/ml;p<0.001）。所有对多糖疫苗无应答的疫苗失败患者随后给予结合疫苗，均产生高抗体应答。大多数受试患者显示补体介导的血清杀菌活性增加。这些数据表明，由于遗传或其他原因，对多糖疫苗的非结合形式不能作出反应的儿童，用结合疫苗进行免疫接种可保护其免受Hib疾病的侵害。
To investigate the basis of the immune defect in children who acquire invasiveHaemophilusdisease despite previous vaccination withHaemophilus influenzaetype b (Hib) polysaccharide vaccine, we determined the ability of vaccine failure patients with low levels of serum anticapsular antibody (<1 μg/ml) to respond to reimmunization. Thirty-four patients, ranging in age from 27 to 61 months, were vaccinated with either Hib polysaccharide (n=20) or Hib polysaccharide-outer membrane protein conjugate vaccine (n=14). All but three of the children had normal serum concentrations of immunoglobulins, including IgG2. The geometric mean serum anticapsular antibody concentration of the group given polysaccharide vaccine increased from 0.27 μg/ml before vaccination to 0.65 μg/ml 1 month later (p<0.05), but the magnitude of the response was nearly 10-fold less than that of 31 age-matched control children given polysaccharide vaccine (6.3 μg/ml,p<0.001). In contrast, all 14 patients with vaccine failure who were given conjugate vaccine showed increases of fivefold or more in serum anticapsular antibody (geometric means 0.35 and 12.8 μg/ml, respectively;p<0.001). All patients with vaccine failure who did not respond to polysaccharide vaccine were subsequently given conjugate vaccine, and all had high antibody responses. Most patients tested showed increased in complement-mediated serum bactericidal activity. These data suggest that immunization with conjugate vaccine confers protection against Hib disease to children who, because of genetic or other reasons, cannot respond to the unconjugated form of the polysaccharide vaccine.
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明尼苏达州儿童接种 b 型多糖疫苗后与 b 型流感嗜血杆菌疾病相关的宿主和细菌因素
DOI：
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发表时间：
1989
期刊：
影响因子：
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作者：
D. Granoff;K. Sheetz;J. Pandey;M. Nahm;J. H. Rambeck;J. L. Jacobs;J. Musser;R. Selander;M. Kabeer;T. Murphy;M. Osterholm
通讯作者：
M. Osterholm
用 b 型流感嗜血杆菌多糖-脑膜炎奈瑟菌外膜蛋白结合疫苗免疫的婴儿对荚膜多糖的免疫启动。
DOI：
10.1016/s0022-3476(87)80336-0
发表时间：
1987
期刊：
The Journal of pediatrics
影响因子：
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作者：
Weinberg,GA;Einhorn,MS;Lenoir,AA;Granoff,PD;Granoff,DM
通讯作者：
Granoff,DM
影响因子：
--
作者：
REIMER, CB;PHILLIPS, DJ;MCDOUGAL, JS
通讯作者：
MCDOUGAL, JS
由来自 b 型流感嗜血杆菌荚膜的高碘酸盐裂解寡糖与蛋白质载体偶联组成的疫苗：人类婴儿启动的结构和时间要求。
DOI：
--
发表时间：
1986
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Anderson,PW;Pichichero,ME;Insel,RA;Betts,R;Eby,R;Smith,DH
通讯作者：
Smith,DH
两名对荚膜多糖疫苗无反应的 IgG2 缺乏症患者对乙型流感嗜血杆菌寡糖-蛋白结合疫苗的反应。
DOI：
10.1056/nejm198608213150807
发表时间：
1986
期刊：
The New England journal of medicine
影响因子：
--
作者：
Insel,RA;Anderson,PW
通讯作者：
Anderson,PW