Curcumin prevents human dendritic cell response to immune stimulants.
Curcumin prevents human dendritic cell response to immune stimulants.
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DOI：
10.1016/j.bbrc.2008.07.051
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发表时间：
2008-09-26
影响因子：
3.1
通讯作者：
Mohapatra, Shyam S.
中科院分区：
文献类型：
--
作者：
Shirley, Shawna A.;Montpeti, Alison J.;Lockey, R. F.;Mohapatra, Shyam S.
姜黄素是一种在印度香料姜黄中发现的化合物，具有抗炎和免疫调节的特性，尽管其机制尚不清楚。树突状细胞（dc）在产生免疫应答中起重要作用，姜黄素对树突状细胞的影响尚不清楚。以LPS和Poly I:C为感染模型，研究了姜黄素在DC对细菌和病毒感染的反应中的作用。从人外周血中分离出CD14+单核细胞，在GM-CSF-和il -4补充的培养基中培养，生成未成熟的dc。培养物用姜黄素孵育，用LPS或Poly I:C刺激，进行功能测定。姜黄素通过阻断成熟标志物、细胞因子和趋化因子的表达，减少迁移和内吞作用，阻止dc对免疫刺激物的反应，诱导naïve CD4+ T细胞增殖。这些数据表明姜黄素作为免疫抑制剂具有治疗作用。
Curcumin, a compound found in the Indian spice turmeric, has anti-inflammatory and immunomodulatory properties, though the mechanism remains unclear. Dendritic cells (DCs) are important to generating an immune response and the effect of curcumin on human DCs has not been explored. The role curcumin in the DC response to bacterial and viral infection was investigated in vitro using LPS and Poly I:C as models of infection. CD14+ monocytes, isolated from human peripheral blood, were cultured in GM-CSF- and IL-4-supplemented medium to generate immature DCs. Cultures were incubated with curcumin, stimulated with LPS or Poly I:C and functional assays were performed. Curcumin prevents DCs from responding to immunostimulants and inducing naïve CD4+ T cell proliferation by blocking maturation marker, cytokine and chemokine expression and reducing both migration and endocytosis. These data suggest a therapeutic role for curcumin as an immune suppressant.
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影响因子：
5.4
作者：
AMMON, HPT;SAFAYHI, H;SABIERAJ, J
通讯作者：
SABIERAJ, J
影响因子：
10.2
作者：
Bisht S;Feldmann G;Soni S;Ravi R;Karikar C;Maitra A;Maitra A
通讯作者：
Maitra A
DOI：
10.1073/pnas.88.12.5292
发表时间：
1991-06-01
影响因子：
11.1
作者：
HUANG, TS;LEE, SC;LIN, JK
通讯作者：
LIN, JK
DOI：
10.1385/1-59259-150-7:283
发表时间：
2001-01-01
期刊：
DENDRITIC CELL PROTOCOLS
影响因子：
--
作者：
Pickl, WF;Majdic, O;Knapp, W
通讯作者：
Knapp, W
影响因子：
6.1
作者：
Maheshwari, RK;Singh, AK;Srimal, RC
通讯作者：
Srimal, RC