Daytime Variation in Serum Progesterone During the Mid-Luteal Phase in Women Undergoing In Vitro Fertilization Treatment.
Daytime Variation in Serum Progesterone During the Mid-Luteal Phase in Women Undergoing In Vitro Fertilization Treatment.
复制标题
DOI：
10.3389/fendo.2018.00092
复制
发表时间：
2018
影响因子：
5.2
通讯作者：
Humaidan P
中科院分区：
文献类型：
--
作者：
Thomsen LH;Kesmodel US;Andersen CY;Humaidan P
研究接受体外受精（IVF）的妇女在12小时白天期间黄体中期血清孕酮（P4）是否表现出显著波动，并探讨这些波动的程度是否会影响临床环境中黄体孕酮水平的解释。探索性试点研究。公立医院生育科。10名女性接受IVF治疗。取卵后7天，患者接受频繁的重复采血（每60分钟一次，持续12小时，在其中两个小时内，每15分钟一次）。分析血清样品中的孕酮、雌二醇和黄体生成素（LH）。孕酮和雌二醇的日间波动。P4中位数水平和P4变化幅度之间存在显著的正相关性-P4中位数< 60 nmol/l的女性全天的临床P4水平稳定，而P4中位数> 250 nmol/l的患者表现出周期性的P4峰值，每升数百纳摩尔。无论刺激方案的类型或触发最终卵母细胞成熟的模式如何，以及尽管LH在测量时低于检测限，都观察到这些内源性P4波动。同时，在s-雌二醇中观察到大的波动。在IVF周期中监测早期至中期黄体P4水平可能对计划个体化黄体期支持以增加生殖结局有价值。然而，黄体期监测的先决条件是，单个测量的P4值的有效性是可靠的。我们第一次表明，在低孕酮患者中的单个P4测量相当准确地反映了黄体功能，并且该测量可用于检测需要额外外源性黄体P4给药的IVF患者。
To investigate whether mid-luteal serum progesterone (P4) exhibits significant fluctuations during a 12-h daytime period in women undergoing in vitro fertilization (IVF) and to explore whether the extent of these fluctuations could impact the interpretation of luteal progesterone levels in a clinical setting. Explorative pilot study. Public hospital-based fertility unit. Ten women undergoing IVF treatment. Seven days after oocyte pick-up, patients underwent frequent repeated blood sampling (every 60 min for 12 h and during two of these hours, every 15 min). Serum samples were analyzed for progesterone, estradiol, and luteinizing hormone (LH). Daytime fluctuations in s-progesterone and s-estradiol. There was a significant positive correlation between median P4 levels and the magnitude of P4 variations—women with median P4 < 60 nmol/l had clinically stable P4 levels throughout the day, while patients with median P4 > 250 nmol/l exhibited periodic P4 peaks of several hundred nanomoles per liter. These endogenous P4 fluctuations were observed irrespective of the type of stimulation protocol or mode of triggering of final oocyte maturation and despite the fact that LH was under the detection limit at the time of measurement. Simultaneously, large fluctuations were seen in s-estradiol. Monitoring of early to mid-luteal P4 levels in IVF cycles may be valuable in the planning of individualized luteal phase support in the attempt to increase reproductive outcomes. The prerequisite for luteal phase monitoring is, however, that the validity of a single measured P4 value is reliable. We show for the first time, that a single P4 measurement in the low progesterone patient quite accurately reflects the corpus luteum function and that the measurement can be used to detect IVF patients with a need of additional exogenous luteal P4 administration.
登录
查看更多内容
DOI：
10.1016/j.prostaglandins.2006.01.002
发表时间：
2006-05-01
影响因子：
2.9
作者：
Bah, Mamadou M.;Acosta, Tomas J.;Skarzynski, Dariusz J.
通讯作者：
Skarzynski, Dariusz J.
影响因子：
4
作者：
Humaidan, P;Bungum, L;Lindenberg, S
通讯作者：
Lindenberg, S
影响因子：
3.2
作者：
ROSSMANITH, WG;LAUGHLIN, GA;YEN, SSC
通讯作者：
YEN, SSC
影响因子：
2.8
作者：
Nogueira, MFG;Melo, DS;Barros, CM
通讯作者：
Barros, CM
影响因子：
5.8
作者：
ROSSMANITH, WG;LAUGHLIN, GA;YEN, SSC
通讯作者：
YEN, SSC