Human rhinovirus C: Age, season, and lower respiratory illness over the past 3 decades.
Human rhinovirus C: Age, season, and lower respiratory illness over the past 3 decades.
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DOI：
10.1016/j.jaci.2012.09.033
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发表时间：
2013-01
影响因子：
14.2
通讯作者：
Miller, E. Kathryn
中科院分区：
文献类型：
--
作者：
Linder, Jodell E.;Kraft, David C.;Mohamed, Yassir;Lu, Zengqi;Heil, Luke;Tollefson, Sharon;Saville, Benjamin R.;Wright, Peter F.;Williams, John V.;Miller, E. Kathryn
人类鼻病毒（HRV）引起普通感冒，最近发现的HRV-C越来越多地与儿童和哮喘患者等人群的下呼吸道疾病相关。确定HRV-C如何与呼吸系统疾病相关，并评估20年来患病率和物种的变化。在范德比尔特疫苗诊所对5岁以下儿童进行了为期21年的前瞻性研究。对急性护理访视时出现上呼吸道或下呼吸道疾病的儿童的鼻洗液标本进行HRV和HRV阳性基因分型检测。比较有或无HRV以及不同HRV类型儿童的人口统计学和临床特征。从1982年到2003年，在来自2009名儿童的527份标本中，有190份（36%）检出了HRV。其中36%为HRV-C。年龄（P = 0.039）和患病月份（P <0.001）与HRV感染和HRV种类相关。与HRV-A相比，HRV-C与下呼吸道疾病显著相关（P = 0.014）。HRV-A和HRV-C的患病率在整个21年期间波动; HRV-C在冬季更普遍（P = .058）。HRV-C不是一种新病毒，但几十年来一直与该人群的儿童下呼吸道疾病密切相关。病毒流行率发生时间变化，季节可以预测病毒种类。我们的研究结果具有诊断，预防和治疗策略的影响，由于疾病的季节和严重程度的变化的基础上的HRV感染的物种。
Human rhinoviruses (HRVs) cause common colds, and the recently discovered HRV-C is increasingly associated with lower respiratory illness among populations such as children and asthmatic patients. To determine how HRV-C is associated with respiratory illness and to evaluate changes in prevalence and species over 2 decades. A prospective study of children younger than 5 years was performed at the Vanderbilt Vaccine Clinic over a 21-year period. Nasal-wash specimens from children presenting with upper or lower respiratory illness at acute care visits were tested for HRV and HRV-positives genotyped. Demographic and clinical features were compared between children with or without HRV, and with different HRV species. HRV was detected in 190 of 527 (36%) specimens from a population of 2009 children from 1982 through 2003. Of these, 36% were HRV-C. Age (P = .039) and month of illness (P < .001) were associated with HRV infection and HRV species. HRV-C was significantly associated with lower respiratory illness, compared with HRV-A (P = .014). HRV-A and HRV-C prevalence fluctuated throughout the 21-year period; HRV-C was more prevalent during winter (P = .058). HRV-C is not a new virus but has been significantly associated with childhood lower respiratory illness in this population for several decades. Temporal changes in virus prevalence occur, and season may predict virus species. Our findings have implications for diagnostic, preventive, and treatment strategies due to the variation in disease season and severity based on species of HRV infection.
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DOI：
10.1183/09031936.00092410
发表时间：
2011-05
期刊：
The European respiratory journal
影响因子：
--
作者：
Bizzintino J;Lee WM;Laing IA;Vang F;Pappas T;Zhang G;Martin AC;Khoo SK;Cox DW;Geelhoed GC;McMinn PC;Goldblatt J;Gern JE;Le Souëf PN
通讯作者：
Le Souëf PN
DOI：
10.1016/j.jcv.2009.03.008
发表时间：
2009-05
期刊：
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology
影响因子：
--
作者：
Greer RM;McErlean P;Arden KE;Faux CE;Nitsche A;Lambert SB;Nissen MD;Sloots TP;Mackay IM
通讯作者：
Mackay IM
DOI：
10.1016/j.jaci.2008.10.007
发表时间：
2009-01
期刊：
The Journal of allergy and clinical immunology
影响因子：
--
作者：
Miller EK;Edwards KM;Weinberg GA;Iwane MK;Griffin MR;Hall CB;Zhu Y;Szilagyi PG;Morin LL;Heil LH;Lu X;Williams JV;New Vaccine Surveillance Network
通讯作者：
New Vaccine Surveillance Network
影响因子：
5.4
作者：
Ledford, RM;Patel, NR;Pevear, DC
通讯作者：
Pevear, DC
DOI：
10.1016/j.jcv.2007.03.012
发表时间：
2007-06
期刊：
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology
影响因子：
--
作者：
McErlean P;Shackelton LA;Lambert SB;Nissen MD;Sloots TP;Mackay IM
通讯作者：
Mackay IM