Thalamocortical interactions.

Thalamocortical interactions.
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DOI:
10.1016/j.conb.2012.03.005
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发表时间:
2012-08
影响因子:
5.7
通讯作者:
Sherman SM
Sherman SM
中科院分区:
医学2区
文献类型:
--
作者:
Sherman SM

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谷氨酸能通路主导着大脑中的信息处理,但这些通路并不是同质的。它们包括两种不同的类型:第 1 类,携带用于处理的主要信息,以及第 2 类,起调节作用。识别电路中的 1 类输入可以更好地理解其功能。此外,识别丘脑核的 1 类输入告诉我们其主要功能(例如,LGN 是视网膜 1 类输入的中继),这种识别导致丘脑中继分为一阶和更高阶:前者从皮层下源接收 1 类输入;后者从皮层下源接收 1 类输入。后者来自皮质的第 5 层,然后将其传递到另一个皮质区域。当一个皮质区域与另一个区域直接连接时,它通常通过这些更高阶的中继具有并行的、跨丘脑的连接。这导致了对皮质功能的新认识并提出了许多新问题。
Glutamatergic pathways dominate information processing in the brain, but these are not homogeneous. They include two distinct types: Class 1, which carries the main information for processing, and Class 2, which serves a modulatory role. Identifying the Class 1 inputs in a circuit can lead to a better understanding of its function. Also, identifying Class 1 inputs to a thalamic nucleus tells us its main function (e.g., LGN is the relay of retinal Class 1 input), and such identification leads to a division of thalamic relays into first and higher order: the former receives Class 1 inputs from subcortical sources; the latter, from layer 5 of cortex, which it then relays to another cortical area. When a cortical area directly connects with another, it often has a parallel, transthalamic connection through these higher order relays. This leads to a novel appreciation of cortical functioning and raises many new questions.
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