Relationship between structural and functional connectivity change across the adult lifespan: A longitudinal investigation.
Relationship between structural and functional connectivity change across the adult lifespan: A longitudinal investigation.
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DOI：
10.1002/hbm.23403
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发表时间：
2017-01
影响因子：
4.8
通讯作者：
Walhovd, Kristine B.
中科院分区：
文献类型：
--
作者：
Fjell, Anders M.;Sneve, Markus H.;Grydeland, Hakon;Storsve, Andreas B.;Amlien, Inge K.;Yendiki, Anastasia;Walhovd, Kristine B.
关键词：
广泛的努力致力于了解大脑的功能（FC）和结构连接（SC）。FC通常通过功能性磁共振成像（fMRI）测量，并被概念化为不同区域之间大脑活动的同步程度。SC通常通过白色物质（WM）性质的测量来索引，例如通过扩散加权成像（DWI）。促进家庭和科学部门有着内在的联系，因为跨区域活动的协调最终取决于通过结构联系实现的快速有效的信息传递。FC和SC之间的融合已在特定网络中得到证明，尤其是默认模式网络（DMN）。然而，目前还不知道FC在多大程度上受到主要WM域的约束，以及FC和SC是否随时间一起变化。在这里，120名参与者（20-85岁）在两个时间点进行了测试，间隔3.3年。静息状态下的功能磁共振成像用于测量FC，DWI用于测量WM微结构作为SC的指标。TRACULA，FreeSurfer的一部分，用于18个主要WM束的自动纤维束成像。皮质区域与纤维束成像定义的紧密结构耦合在功能水平上只有弱相关。DMN的某些区域表现出FC和SC变化之间的适度关系，但在大多数情况下，这两个措施独立变化。主要结论是，SC和FC的解剖排列似乎仅限于特定的网络和束，SC和FC的变化不一定是强相关的。
Extensive efforts are devoted to understand the functional (FC) and structural connections (SC) of the brain. FC is usually measured by functional magnetic resonance imaging (fMRI), and conceptualized as degree of synchronicity in brain activity between different regions. SC is typically indexed by measures of white matter (WM) properties, e.g. by diffusion weighted imaging (DWI). FC and SC are intrinsically related, in that coordination of activity across regions ultimately depends on fast and efficient transfer of information made possible by structural connections. Convergence between FC and SC has been shown for specific networks, especially the default mode network (DMN). However, it is not known to what degree FC is constrained by major WM tracts and whether FC and SC change together over time. Here, 120 participants (20-85 years) were tested at two time points, separated by 3.3 years. Resting-state fMRI was used to measure FC, and DWI to measure WM microstructure as an index of SC. TRACULA, part of FreeSurfer, was used for automated tractography of 18 major WM tracts. Cortical regions with tight structural couplings defined by tractography were only weakly related at the functional level. Certain regions of the DMN showed a modest relationship between change in FC and SC, but for the most part, the two measures changed independently. The main conclusions are that anatomical alignment of SC and FC seems restricted to specific networks and tracts, and that changes in SC and FC are not necessarily strongly correlated.
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影响因子：
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作者：
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